52333-43-4

Upstream product

• 431-03-8 dimethylglyoxal 
• 1575-37-7 4-Bromo-benzene-1,2-diamine 
• 38875-53-5 5-bromo-pyridine-2,3-diamine 

Downstream Products

• 7154-32-7 dimethyl-2,3 pyrido<2,3-b>pyrazine 

Relevant academic research and scientific papers

A zirconium Schiff base complex immobilized on starch-coated maghemite nanoparticles catalyzes heterogeneous condensation of 1,2-diamines with 1,2-dicarbonyl compounds

A magnetically separable zirconium Schiff base nanocatalyst was synthesized under ultrasonic agitation. TEM images revealed a uniform spherical particle shape with average size of 10-14 nm for the as-prepared catalyst. The catalytic performance of ZrOL2@SMNP in the heterogeneous condensation of various 1,2-diamines and 1,2-dicarbonyls for the synthesis of heterocyclic compounds in ethanol has been explored.

A novel protocol for selective synthesis of monoclinic zirconia nanoparticles as a heterogeneous catalyst for condensation of 1,2-diamines with 1,2-dicarbonyl compounds

ZrO2 nanocatalyst has been obtained successfully using novel and safe agents through a simple and safe sol-gel method (polymerizing-complexing) and characterized by XRD, FT-IR, Raman spectroscopies and transmission electron microscopy (TEM). Raman spectroscopies and XRD results indicated only formation of monoclinic zirconia. TEM images revealed spherical nanoparticles with 20-40 nm diameter range. The spectral and analysis data confirmed the effectiveness of the method for preparation of monoclinic zirconia by preventing grain growth or agglomeration of particles. The nanostructured ZrO2 exhibited high efficiency in catalyzing condensation of various 1,2-diamine and 1,2-dicarbonyl compounds for the synthesis of heterocyclic compounds. The recovery of the title heterogeneous nanocatalyst was easy and efficient and its catalytic activity was strikingly different from the bulk one.

Reusable α-MoO3 nanobelts catalyzes the green and heterogeneous condensation of 1,2-diamines with carbonyl compounds

Crystalline nanobelts of α-MoO3 have been obtained successfully using novel and safe agents through a simple and safe sol-gel method (polymerizing-complexing) and characterized by XRD, FT-IR, Raman spectroscopies, high resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM) and the temperature programmed desorption (TPD) of ammonia. An orthorhombic lattice system for nano-MoO3 was established. The HRTEM images showed that the nanobelt morphology of α-MoO3 mostly ranged from 20-70 nm in width and 200-400 nm in length. The ammonia TPD profile demonstrated strong acidic sites. The spectral and analysis data confirmed the effectiveness of the method for the preparation of α-MoO3 nanobelts by prevention of grain growth or agglomeration of the particles. The nanostructured MoO3 exhibited a high efficiency in catalyzing the condensation reaction of various 1,2-diamine and carbonyl compounds for synthesis of heterocyclic compounds. The recovery of the title heterogenous nanocatalyst was easy and efficient and its catalytic activity was strikingly different from the bulk material.

Microwave-assisted synthesis of quinoxaline derivatives using glycerol as a green solvent

A rapid, efficient, and reliable catalyst-free procedure for the synthesis of quinoxaline derivatives in glycerol under focused microwave irradiation was developed. The reaction proceeded in glycerol without any catalyst making this methodology valuable from both economic and environmental viewpoints.

Microwave-assisted solvent-free synthesis and in vitro antibacterial screening of quinoxalines and pyrido[2, 3b]pyrazines

We report herein the microwave assisted synthesis, without solvents and catalysts, of 6-substituted quinoxalines and 7-substituted pyrido[2,3b] pyrazines. The compounds were obtained in good yields and short reaction times using the mentioned procedure and two new structures are reported. A complete 1H-and 13C-NMR assignment was performed using 1D and 2D-NMR. Additionally, an in vitro screening was performed on Gram-positive and Gram-negative bacteria using amoxicillin as positive reference. Compounds bearing a pyridyl group tended to have higher antibacterial activity, but the best activity against Bacillus subtilis and Proteus mirabilis was observed with quinoxaline derivatives.

Microwave-assisted synthesis of quinoxalines in peg-400

A rapid and efficient procedure for the synthesis of quinoxaline derivatives has been achieved by condensation of aryl-1,2-diamines with 1,2-dicarbonyl compounds catalyzed by polyethylene glycol under CEM-focused microwave-irradiation conditions. Copyright

Heterocyclizations in the pyrido[2,3-b]pyrazine series

In this paper, we report the results of heterocyclizations in the pyrido[2,3-b]pyrazine series to give the pyrido[2,3-e] or [3,2-e]pyrrolo[1,2- a]pyrazine. The Clauson-Kaas reaction on 2,3-diaminopyridine is investigated; regioselectivity on the 3-amino group is shown by 1H- and 13C-nmr. Synthesis and reactivity of the original pyrazino[2,3-g]indolizine series is also reported.

Cine and normal substitution reaction on substituted 7-bromo-5-azaquinoxalines by secondary amines

7-Bromo-3-phenyl-5-azaquinoxaline (I), 7-bromo-2,3-dimethyl-5-azaquinoxaline (II) and 7-bromo-2,3-diphenyl-5-azaquinoxaline (III) have been synthesized and their nucleophilic substitution reactions with pyrrolidine, piperidine, morpholine and diethanolami