52333-47-8

Upstream product

• 16867-03-1 2-amino-3-hydroxypyridine 
• 459-57-4 4-fluorobenzaldehyde 
• 5153-69-5 4-fluoro-β-nitrostyrene 
• 456-22-4 4-Fluorobenzoic acid 

Downstream Products

• 1380678-08-9 4-((2-(4-fuorophenyl)oxazolo[4,5-b]pyridin-7-yl)oxy)aniline 
• 1380678-09-0 N-((4-((2-(4-fluorophenyl)oxazolo[4,5-b]pyridin-7-yl)oxy)phenyl)carbamothioyl)-2-phenylacetamide 
• 1380678-05-6 C₁₂H₇FN₂O₂ 
• 1380678-06-7 7-chloro-2-(4-fluorophenyl)oxazolo[4,5-b]pyridine 
• 1380678-07-8 2-(4-fluorophenyl)-7-(4-nitrophenoxy)oxazolo[4,5-b]pyridine 

Relevant academic research and scientific papers

Molecular modeling, density functional theory, ADME prediction and antimicrobial activity studies of 2-(substituted)oxazolo[4,5-: B] pyridine derivatives

In this study, the antimicrobial activities of previously synthesized 2-(substituted)oxazolo[4,5-b]pyridine derivatives toward six bacteria strains and twelve related drug-resistant isolates, and one fungus strain and two related drug-resistant isolates w

Synthesis method of pyridoxazole derivative

The invention provides a synthesis method of a pyridoxazole derivative. The synthesis method comprises the following steps: dissolving 2-amino-3-hydroxypyridine and aldehyde into an organic solvent, carrying out stirring at 70-90 DEG C for 2-3 h, then, ad

Ce(III)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants

An efficient synthesis of a variety of pyridyl benzamides from 2-aminopyridines and nitroolefins is described. This rare-earth-metal-catalyzed reaction provides the corresponding products with broad substrate scope in moderate to excellent yields, in the absence of additives and external oxidants. Water is used as the source of the carbonyl oxygen atom in pyridyl benzamides. Furthermore, 2-substituted oxazolo[4,5-b]pyridines are formed in good yields under the standard conditions when 2-aminopyridin-3-ols are used as the substrates.

Discovery of 3H-Imidazo[4,5-b]pyridines as Potent c-Met Kinase Inhibitors: Design, Synthesis, and Biological Evaluation

To identify novel c-Met inhibitors, sequences and crystal structures of the human kinome were analyzed to find interesting hinge binders that have been underexplored within the tyrosine kinase subfamily. Through this study, the imidazolopyridine ring was selected as a novel c-Met hinge-binding inhibitor scaffold. A series of derivatives was prepared, and the structure-activity relationships were studied. Among these, one compound in particular showed excellent activities in enzymatic and cellular assays, good invitro metabolic stability, and favorable pharmacokinetic parameters. When administered orally, the compound inhibited tumor growth in an NIH-3T3/TPR-Met xenograft model and did not show adverse effects on body weight. The present work not only conceptually demonstrates a new route for designing novel kinase inhibitors by using known structural information of ligand-hinge interactions but also provides a series of imidazolopyridine derivatives as potent c-Met inhibitors.

Anti-inflammatory oxazole[4,5-b]pyridines

The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.