52333-49-0Relevant academic research and scientific papers
Analgesic oxazolopyridine compounds
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, (2008/06/13)
Compound of general formula (I): STR1 in which: X, Y, Z and T each represent, independently of one another, a nitrogen atom, a --CH= group or a group CW, in which W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one
Process for the synthesis of oxazolopyridine compounds
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, (2008/06/13)
Process for the synthesis of compounds of formula (I): STR1 their pyridinium salts and N-oxides, in which formula: the nitrogen of the pyridine ring is situated in the α-, β-, γ- or δ-position with respect to the ring junction; R1 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, substituted or unsubstituted amino, phenyl or cyano group; 0≤m≤2; R2 represents a lower alkyl or cycloalkyl group, a 5- or 6-membered heterocycle containing 1 or 2 hetero atoms, substituted or otherwise, or an aryl group STR2 such that: R3 represents a halogen, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkoxy or a nitro, phenyl, substituted or unsubstituted sulfonyl, cyano, thioalkyl, substituted or unsubstituted amino, substituted or unsubstituted sulfinyl, mercapto, hydroxyl or ester group, 0≤n≤5 employing trimethylsilyl polyphosphate (PPSE) as a cyclization agent and enabling the compounds of formula (I) to be obtained in virtually quantitative yields. The compounds of formula I have anti-inflammatory, analgesic, and antipyretic activity.
2-Aryloxazolo- et pyridines: synthese et acylation par substitution radicalaire
Flouzat, C.,Guillaumet, G.
, p. 899 - 906 (2007/10/02)
Homolytic acylation of protonated 2-aryloxazolo- and pyridines by butyraldehyde and benzaldehyde, as a source of acyl radical, gives products substituted at α and γ position in satisfactory yields.The factors affecting mono- and poly-substit
Anti-inflammatory oxazole[4,5-b]pyridines
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, (2008/06/13)
The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.
