52333-88-7

Basic information

• Product Name: 2-ETHYLOXAZOLO[4,5-B]PYRIDINE
• Synonyms: 2-ETHYLOXAZOLO[4,5-B]PYRIDINE;7-Chloro-4H-benzo[1,4]oxazin-3-one;2-Ethyl[1,3]oxazolo[4,5-b]pyridine
• CAS NO: 52333-88-7
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.17
• Mol File: 52333-88-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 51-53 °C
• Boiling Point: 229.0±13.0 °C(Predicted)
• Appearance: /
• Density: 1.179±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 0.18±0.50(Predicted)
• CAS DataBase Reference: 2-ETHYLOXAZOLO[4,5-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ETHYLOXAZOLO[4,5-B]PYRIDINE(52333-88-7)
• EPA Substance Registry System: 2-ETHYLOXAZOLO[4,5-B]PYRIDINE(52333-88-7)

Safety Data

• Hazardous Substances Data: 52333-88-7(Hazardous Substances Data)

Usage

General Description

2-Ethyloxazolo[4,5-b]pyridine is a chemical compound with the molecular formula C7H7NO. It is a heterocyclic compound containing a pyridine ring fused to an oxazole ring with an ethyl group attached to the nitrogen atom. 2-ETHYLOXAZOLO[4,5-B]PYRIDINE is used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential biological activities, including its role as a neuroprotective agent. Additionally, 2-ethyloxazolo[4,5-b]pyridine has also been investigated for its potential use in the development of new materials and as a catalyst in organic synthesis reactions.

Upstream product

• 16867-03-1 2-amino-3-hydroxypyridine 
• 115-80-0 Triethyl orthopropionate 

Relevant articles and documents

A green route for the synthesis of 2-substituted benzoxazole derivatives catalyzed by Al3+-exchanged K10 clay

A new, simple, and efficient protocol is developed for the synthesis of 2-substituted benzoxazole derivatives through N-C-O bond formation using Al 3+-exchanged K10 clay (Al3+-K10) as catalyst. A wide range of benzoxazole derivatives

Mild and efficient synthesis of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines catalyzed by Bi(III) salts under solvent-free conditions

A series of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines was efficiently synthesized from the reactions of o-aminophenols, o-aminothiophenol, o-phenylenediamines, and 2-amino-3- hydroxypyridine with orthoesters in the presence of catalytic amounts of Bi(III) salts, such as Bi(TFA)3, Bi(OTf)3, and BiOClO4 ? xH2O under solvent-free conditions. The remarkable features of this new protocol are high conversion, very short reaction times, cleaner reaction profiles under solvent-free conditions, straightforward procedure, and use of relatively non-toxic catalysts. Springer-Verlag 2007.

Synthesis of novel heterocycles: Oxazolo[4,5-b]pyridines and oxazolo[4,5-d]pyrimidines

Novel purine isosters (title compounds) have been prepared by condensation of the appropriate o-hydroxyaminoazine with ethyl orthoformate; extension to other orthoesters and to benzyl thioacetimidate afford 2-alkyl substituted derivatives of these new fus