52333-88-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-Ethyloxazolo[4,5-b]pyridine is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the development of new compounds with potential therapeutic and pesticidal properties.
Used in Neuroprotective Applications:
As a neuroprotective agent, 2-ethyloxazolo[4,5-b]pyridine is studied for its potential to protect neurons from damage or degeneration, which could be beneficial in the treatment of neurological disorders.
Used in Material Science:
2-Ethyloxazolo[4,5-b]pyridine has been investigated for its potential use in the development of new materials, owing to its unique chemical structure and properties.
Used as a Catalyst in Organic Synthesis:
2-ETHYLOXAZOLO[4,5-B]PYRIDINE has also been explored for its potential as a catalyst in organic synthesis reactions, which could enhance the efficiency and selectivity of various chemical processes.

Upstream product

• 16867-03-1 2-amino-3-hydroxypyridine 
• 115-80-0 Triethyl orthopropionate 

Relevant academic research and scientific papers

A green route for the synthesis of 2-substituted benzoxazole derivatives catalyzed by Al3+-exchanged K10 clay

A new, simple, and efficient protocol is developed for the synthesis of 2-substituted benzoxazole derivatives through N-C-O bond formation using Al 3+-exchanged K10 clay (Al3+-K10) as catalyst. A wide range of benzoxazole derivatives

1,3-Dibromo-5,5-dimethylhydantoin as an efficient homogeneous catalyst for synthesis of benzoxazoles, benzimidazoles, and oxazolo[4,5-b]pyridines

A simple and highly efficient method for synthesis of benzoxazoles, benzimidazoles, and oxazolo[4,5-b]pyridines is described. Condensation of orthoesters with o-substituted anilines or 2-amino-3-hydroxypyridine was performed in the presence of catalytic amounts of commercially available, inexpensive, and moisture-stable 1,3-dibromo-5,5-dimethylhydantoin under solvent-free conditions. The corresponding heterocycles were obtained in good to excellent yields. The main advantages of the present procedure are mild reaction conditions, short reaction times, high yields of products, easy work-up, and absence of solvent. Graphical abstract: [Figure not available: see fulltext.]

Mild and efficient synthesis of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines catalyzed by Bi(III) salts under solvent-free conditions

A series of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines was efficiently synthesized from the reactions of o-aminophenols, o-aminothiophenol, o-phenylenediamines, and 2-amino-3- hydroxypyridine with orthoesters in the presence of catalytic amounts of Bi(III) salts, such as Bi(TFA)3, Bi(OTf)3, and BiOClO4 ? xH2O under solvent-free conditions. The remarkable features of this new protocol are high conversion, very short reaction times, cleaner reaction profiles under solvent-free conditions, straightforward procedure, and use of relatively non-toxic catalysts. Springer-Verlag 2007.

Syntheses of oxazolo[4,5-b]pyridenes and [4,5-d]pyrimidines

Oxazolo[4,5-b]pyridines and [4,5-d]pyrimidines and their 2-substituted compounds have been prepared respectively by condensation of orthoesters of thioimidates derivatives with 2-amino-3-hydroxypyridine and 4-amino-5-hydroxypyrimidine.

Synthesis of novel heterocycles: Oxazolo[4,5-b]pyridines and oxazolo[4,5-d]pyrimidines

Novel purine isosters (title compounds) have been prepared by condensation of the appropriate o-hydroxyaminoazine with ethyl orthoformate; extension to other orthoesters and to benzyl thioacetimidate afford 2-alkyl substituted derivatives of these new fus

Anti-inflammatory oxazole[4,5-b]pyridines

The various isomers of oxazolo- and thiazolopyridines having utility as antiinflammatory, antipyretic and analgesic agents are prepared by condensation of an appropriate amino-hydroxypyridine or amino-mercaptopyridine with a carboxylic acid, halide or anhydride.