52334-81-3

Basic information

• Product Name: 2-Chloro-5-trifluoromethylpyridine
• Synonyms: 2-choro-5-(trifluoromethyl) pyridine;2-chloride-5-(trifluoromethoxy)pyridine;2-Cchloro-5-(Trifluoromethyl)pyridine;2-Chloro-5-(trifluoromethyl)pyridine, 98+%;2-Chloro-5-(Trifluoromethyl)Py;2-Chloro-5-(trifluoromethyl)pyridine97%;2-CHLORO-5-TRIFLUOROMETHYLPYRIDINE 98.0%;2-Chloro-5-Tirfluoromethyl Pyridine
• CAS NO: 52334-81-3
• Molecular Formula: C₆H₃ClF₃N
• Molecular Weight: 181.54
• EINECS: 257-856-5
• Product Categories: blocks;FluoroCompounds;Pyridines;Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Halides;Pyridines derivates;Chloropyridines;Halopyridines;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;API Intermediate;Fluorine series
• Mol File: 52334-81-3.mol
• Article Data: 24

Chemical Properties

• Melting Point: 32-34 °C(lit.)
• Boiling Point: 152 °C
• Flash Point: >230 °F
• Appearance: White to yellow/Crystalline Low Melting Solid
• Density: 1.417 g/mL at 25 °C(lit.)
• Storage Temp.: 0-6°C
• PKA: -2.57±0.10(Predicted)
• BRN: 3649688
• CAS DataBase Reference: 2-Chloro-5-trifluoromethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-trifluoromethylpyridine(52334-81-3)
• EPA Substance Registry System: 2-Chloro-5-trifluoromethylpyridine(52334-81-3)

Safety Data

• Hazard Codes: Xi,Xn,T,F
• Statements: 36/37/38-20/21/22-25-11
• Safety Statements: 26-37/39-36/37/39-45-22-16
• RIDADR: 2811
• WGK Germany: 3
• RTECS: US7530000
• TSCA: T
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 52334-81-3(Hazardous Substances Data)

Usage

Synthesis

2-Chloro-5-trifluoromethylpyridine can be synthesized by fluorination of 2-chloro-5-trichloromethylpyridine.

Chemical Properties

white to yellowish crystalline low melting solid

Uses

2-Chloro-5-(trifluoromethyl)pyridine may be employed as model substrate to investigate the regioexhaustive functionalization.

General Description

2-Chloro-5-(trifluoromethyl)pyridine is a chloro(trifluoromethyl) pyridine.

InChI:InChI=1/C6H3ClF3N/c7-5-2-1-4(3-11-5)6(8,9)10/h1-3H

Synthetic route

3-(trifluoromethyl)pyridine (3796-23-4) → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With 1% Pd on activated carbon; chlorine at 235℃; for 24h; Temperature; Reagent/catalyst; Inert atmosphere;	94.9%

2-chloro-5-(Trichloromethyl)-pyridine (69045-78-9) → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With hydrogen fluoride; mercury(II) oxide	87%
With antimony(III) fluoride for 0.166667h; Heating;	54.5%
With hydrogen fluoride
With hydrogen fluoride at 130℃; Temperature;

3-Methylpyridine (108-99-6) → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With magnesium fluoride; hydrogen fluoride; chlorine at 220 - 280℃; for 8h; Temperature; Reagent/catalyst; Inert atmosphere;	76.7%

2-chloro-5-trifluoromethylpyridine 1-oxide (261956-65-4) → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate In dichloromethane at 31℃; for 16h; Sealed tube; Irradiation;	59%

3-(trifluoromethyl)pyridine-N-oxide (22253-72-1) → 2-chloro-5-trifluoromethylpyridine (52334-81-3) + 2-chloro-3-trifluoromethyl-pyridine (65753-47-1)

Conditions	Yield
Stage #1: 3-(trifluoromethyl)pyridine-N-oxide With trichlorophosphate In 1,2-dichloro-ethane at 105 - 125℃; for 7h; Stage #2: With triethylamine In 1,2-dichloro-ethane at -30 - -20℃; for 3h;	A 25.34% B 50.34%

2-choro-5-iodopyridine (69045-79-0) + trimethylsilyl 2-chloro-2,2-difluoroacetate → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With potassium fluoride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide at 90℃; for 4h; Sealed tube; Inert atmosphere;	38%
With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; silver fluoride In N,N-dimethyl-formamide at 100℃; for 1h; Inert atmosphere; Sealed tube; chemoselective reaction;	98 %Spectr.

2-choro-5-iodopyridine (69045-79-0) + sodium 2,2,2-trifluoroacetate (2923-18-4) → 2,5-bis(trifluoromethyl)pyridine (20857-44-7) + 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With 1-methyl-pyrrolidin-2-one; copper(l) iodide at 160℃; for 4h;	A 7 % Chromat. B 85 % Chromat.

2-chloro-5-(Trichloromethyl)-pyridine (69045-78-9) → 2-chloro-5-trifluoromethylpyridine (52334-81-3) + 2-fluoro-5-(trifluoromethyl)pyridine (69045-82-5)

Conditions	Yield
With antimony(III) fluoride

6-Chloro-3-pyridinecarboxylic acid (5326-23-8) + sulfur tetrafluoride → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With hydrogen fluoride In (2S)-N-methyl-1-phenylpropan-2-amine hydrate
With hydrogen fluoride
With sodium hydroxide; hydrogen fluoride

6-hydroxy-3-pyridinecarboxylic acid (5006-66-6) + sulfur tetrafluoride → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With phosphorus pentachloride In water

2-hydroxy-5-(trifluoromethyl)pyridine (33252-63-0) → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With phosphorus pentachloride In water
With trichlorophosphate In N-methyl-acetamide; water

antimony(III) fluoride (7783-56-4) + 2-chloro-5-(Trichloromethyl)-pyridine (69045-78-9) → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

6-hydroxy-3-pyridinecarboxylic acid (5006-66-6) + sulfur tetrafluorde + 5-(trifluoromethyl)-2(1H)-pyridone (33252-63-0) + phosphorus pentachloride (10026-13-8, 874483-75-7) → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With trichlorophosphate In water

2-choro-5-iodopyridine (69045-79-0) + (trifluoromethyl)triethylsilane (120120-26-5) → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide at 20 - 60℃; Inert atmosphere;	69 %Spectr.

Langlois reagent (2926-29-6) + 6-chloropyridin-3-ylboronic acid (444120-91-6) → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With tert.-butylhydroperoxide; tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium hydrogencarbonate In methanol; water at 0 - 20℃; for 12h;	85 %Spectr.

2-cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium triflate (1214756-50-9) + 6-chloropyridin-3-ylboronic acid (444120-91-6) → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With 2,4,6-trimethyl-pyridine; fluorobenzene; copper diacetate In ethyl acetate at 20℃; for 20h; Inert atmosphere;	16 %Spectr.

(6-chloropyridin-3-yl)(mesityl)iodonium triflate + (trifluoromethyl)trimethylsilane (81290-20-2) → 2-chloro-5-trifluoromethylpyridine (52334-81-3)

Conditions	Yield
With potassium fluoride; copper(l) iodide; triphenylphosphine In N,N-dimethyl-formamide at 65℃; for 12h; regioselective reaction;	72 %Spectr.

3-Methylpyridine (108-99-6) → 2,6-dichloro-3-(trifluoromethyl)pyridine (55304-75-1) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) + 2-chloro-3-trifluoromethyl-pyridine (65753-47-1)

Conditions	Yield
With hydrogen fluoride; chlorine at 200 - 400℃; for 30h; Large scale;	A 47.7 %Chromat. B 3.7 %Chromat. C 14.5 %Chromat.

3-Hydroxybenzyl alcohol (620-24-6) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → [3-[[5-(trifluoromethyl)-2-pyridyl]oxy]phenyl]methanol (1020325-22-7)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 95 - 105℃; for 5h; Product distribution / selectivity;	100%
With potassium carbonate In N,N-dimethyl-formamide at 90 - 95℃; for 16h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 16h; Product distribution / selectivity;	53%
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 16h;	53%
With potassium carbonate In N,N-dimethyl-formamide at 95℃; for 16h;	53%

5-bromo-2-chlorophenol (183802-98-4) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → 2-(5-bromo-2-chlorophenoxy)-5-(trifluoromethyl)pyridine (1020330-54-4)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 110℃; for 12h;	100%

8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-{1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl}-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine (1403396-21-3) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → 8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-3-(1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}cyclopropyl)-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine (1403396-51-9)

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,2-dimethoxyethane; water at 130℃; for 1.5h; Microwave irradiation;	100%

(7S)-7-methyl-6,7-dihydropyrazolo[1,5-a]pyrazine-4 (5H)-one + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → C13H11F3N4O

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 90℃; for 40h; Sealed tube; Inert atmosphere;	100%

3-Bromophenol (591-20-8) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → 2-(3-bromophenoxy)-5-(trifluoromethyl)pyridine (693828-63-6)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 16h; Inert atmosphere;	99%
With potassium carbonate In N,N-dimethyl-formamide at 110℃;

Thien-3-ylboronic acid (6165-69-1) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → 2-(thiophen-3-yl)-5-(trifluoromethyl)pyridine (1092384-65-0)

Conditions	Yield
With dichloro bis((p-dimethylaminophenyl)-ϖ-di-tert-butylphosphine)palladium(II); triethylamine In water at 20℃; for 19h; Suzuki-Miyaura coupling; Inert atmosphere;	99%

trimethoxonium tetrafluoroborate (420-37-1) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → C7H6ClF3N(1+)*BF4(1-) (1622456-59-0)

Conditions	Yield
In dichloromethane at 20℃;	99%

triethyloxonium fluoroborate (368-39-8) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → 1-ethyl-5-trifluoromethyl-2-chloropyridinium tetrafluoroborate (1622456-61-4)

Conditions	Yield
In dichloromethane at 20℃;	99%

2-chloro-5-trifluoromethylpyridine (52334-81-3) + 4-tert-butylphenylboronic acid (123324-71-0) → 2-(4-(tert-butyl)phenyl)-5-(trifluoromethyl)pyridine

Conditions	Yield
With palladium diacetate; potassium carbonate; nixantphos In tetrahydrofuran; water at 20℃; for 6h; Suzuki-Miyaura Coupling;	99%

2-chloro-5-trifluoromethylpyridine (52334-81-3) + tributyl(thien-2-yl)stannane (54663-78-4) → 2-(thiophen-2-yl)-5-(trifluoromethyl)pyridine

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In toluene for 16h; Inert atmosphere; Reflux;	99%

2,4-di-tert-Butylphenol (96-76-4) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → 1-<2-(5-trifluoromethylpyridyl)>-2-hydroxy-3,5-di-tert-butylbenzene

Conditions	Yield
With potassium tert-butylate In ammonia at -78℃; for 1h; Irradiation; add of 1,3-dinitrobenzene or galvinoxyl;	98%

2-chloro-5-trifluoromethylpyridine (52334-81-3) + Benzimidazol-2-thiol (134469-07-1) → 2-<5-(trifluoromethyl)pyridin-2-ylsulfanyl>-1H-benzimidazole

Conditions	Yield
With potassium tert-butylate for 0.5h; Irradiation;	98%
With sodium hydroxide 2.) DMF, reflux, 3 h; Yield given. Multistep reaction;

2-chloro-5-trifluoromethylpyridine (52334-81-3) + 2-hydroxyethanethiol (60-24-2) → 2-<5-(trifluoromethyl)pyridin-2-ylsulfanyl>ethanol

Conditions	Yield
With potassium tert-butylate for 0.166667h; Irradiation;	98%

2-chloro-5-trifluoromethylpyridine (52334-81-3) + di-4-methoxyphenylzinc (97302-05-1) → 2-(4-methoxyphenyl)-5-(trifluoromethyl)pyridine (296776-84-6)

Conditions	Yield
With tripiperidino-phosphine; nickel dichloride In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 60℃; for 1h; Negishi cross-coupling reaction;	98%

2-chloro-5-trifluoromethylpyridine (52334-81-3) + 1H-Pyrazolo[3,4-b]pyridine (271-73-8) → 1-(4-(trifluoromethyl)pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; zinc diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; for 16h; Buchwald-Hartwig Coupling; Inert atmosphere;	98%

2-chloro-5-trifluoromethylpyridine (52334-81-3) + hydroquinone (123-31-9) → 2-(4-hydroxyphenoxy)-5-trifluoromethylpyridine (69045-85-8)

Conditions	Yield
With sodium hydrogensulfite; potassium hydroxide In N,N-dimethyl-formamide at 50 - 90℃; for 6h; Temperature; Reagent/catalyst;	97.8%
With potassium carbonate In N,N-dimethyl-formamide at 60 - 90℃; for 4h;	75%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;

N,N-dimethyl-cyclohexanamine (98-94-2) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → N,N-dimethyl-5-(trifluoromethyl)pyridine-2-amine (136539-99-6) + Cyclohexyl-methyl-(5-trifluoromethyl-pyridin-2-yl)-amine (136539-98-5)

Conditions	Yield
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h;	A 2% B 97%

2-chloro-5-trifluoromethylpyridine (52334-81-3) → 5,5’-bis(trifluoromethyl)-2,2’-bipyridine (142946-80-3)

Conditions	Yield
With potassium hydroxide In water; N,N-dimethyl-formamide at 35℃; for 12h; Ullmann Condensation; Inert atmosphere;	97%
With manganese; nickel(II) bromide trihydrate In N,N-dimethyl-formamide at 20 - 60℃; for 20h; Inert atmosphere;	70%
With [2,2]bipyridinyl; nickel diacetate; sodium tert-pentoxide In tetrahydrofuran at 25℃; for 0.0377778h;	57%

2-chloro-5-trifluoromethylpyridine (52334-81-3) + 2-mercapto-3H-quinazolin-4-one (13906-09-7) → 2-<5-(trifluoromethyl)pyridin-2-ylsulfanyl>quinazolin-4(3H)-one

Conditions	Yield
With potassium tert-butylate for 0.416667h; Irradiation;	97%

2-chloro-5-trifluoromethylpyridine (52334-81-3) + ethyl 3-methylpyrazole-4-carboxylate (85290-78-4) → ethyl 3-methyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazole-4-carboxylate

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 100℃;	97%

2-chloro-5-trifluoromethylpyridine (52334-81-3) + 2,4-dimethoxypyrimidin-5-ylboronic acid (89641-18-9) → 2,4-dimethoxy-5-(5-(trifluoromethyl)pyridin-2-yl)pyrimidine (1334531-16-6)

Conditions	Yield
With potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); tetrabutylammomium bromide In 1-methyl-pyrrolidin-2-one; water; toluene at 90℃; for 5h; Suzuki-Miyaura cross-coupling; Continuous flow reactor; Inert atmosphere;	97%

2-chloro-5-trifluoromethylpyridine (52334-81-3) + 4-hydroxy-benzaldehyde (123-08-0) → 4-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzaldehyde (103962-21-6)

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 140℃; for 10h;	97%
Stage #1: 4-hydroxy-benzaldehyde With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: 2-chloro-5-trifluoromethylpyridine In N,N-dimethyl-formamide at 20 - 105℃; for 10h;

dmap (1122-58-3) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → 1-(5-trifluoromethyl-2-pyridyl)-4-(dimethylamino)pyridinium chloride

Conditions	Yield
In N,N-dimethyl-formamide at 120℃; for 3h; Temperature;	97%

3-(2,6-dichloro-4-(benzyloxy)phenoxy)-1-propyl alcohol + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → 1-benzyloxy-3,5-dichloro-4-[3-(5-trifluoromethylpyridin-2-yloxy)propyloxy]benzene

Conditions	Yield
With hydrogenchloride; sodium hydroxide In n-heptane; water	96.3%
In ice-water; N,N-dimethyl-formamide	67%

N,N'-dimethylbenzylamine (103-83-3) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → N,N-dimethyl-5-(trifluoromethyl)pyridine-2-amine (136539-99-6) + Benzyl-methyl-(5-trifluoromethyl-pyridin-2-yl)-amine

Conditions	Yield
In tetrahydrofuran at 100℃; under 6000480 Torr; for 96h;	A 96% B 2%

2-chloro-5-trifluoromethylpyridine (52334-81-3) + 4-methoxy-phenol (150-76-5) → 5-(trifluoromethyl)-2-(4-methoxyphenoxy)pyridine (69045-86-9)

Conditions	Yield
With aluminum oxide; potassium fluoride In N,N-dimethyl-formamide at 120℃; for 5h;	96%
In water; dimethyl sulfoxide

2-chloro-5-trifluoromethylpyridine (52334-81-3) + phenylboronic acid (98-80-6) → 2-phenyl-5-(trifluoromethyl)pyridine (188527-56-2)

Conditions	Yield
With palladium diacetate; potassium carbonate; nixantphos In tetrahydrofuran; water at 20℃; for 6h; Suzuki-Miyaura Coupling;	96%
Stage #1: 2-chloro-5-trifluoromethylpyridine; phenylboronic acid With palladium diacetate; (R)-6-dicyclohexylphoshino-6'-diphenylphosphino-3,3'-dimethoxy-2,2',4,4'-tetramethyl-1,1'-biphenyl In dodecane; butan-1-ol at 25℃; for 0.0833333h; Suzuki-Miyaura Coupling; Inert atmosphere; Glovebox; Stage #2: With cesiumhydroxide monohydrate In dodecane; water; butan-1-ol at 25℃; Suzuki-Miyaura Coupling; Inert atmosphere; Glovebox;	95%
With dichloro bis((p-dimethylaminophenyl)-ϖ-di-tert-butylphosphine)palladium(II); triethylamine In water at 20℃; for 24h; Suzuki-Miyaura coupling; Inert atmosphere;	94%

p-hydroxymethylphenylboronic acid (59016-93-2) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → [4-(5-trifluoromethyl-pyridin-2-yl)-phenyl]-methanol (613239-75-1)

Conditions	Yield
With C37H44ClN2O3PPd; caesium carbonate In water at 100℃; for 12h; Suzuki Coupling; Schlenk technique; Inert atmosphere;	96%
palladium dichloride

ethyl 3-isopropyl-1H-pyrazole-4-carboxylate (342026-17-9) + 2-chloro-5-trifluoromethylpyridine (52334-81-3) → ethyl 3-isopropyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazole-4-carboxylate

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 100℃;	96%

2-chloro-5-trifluoromethylpyridine (52334-81-3) + (RS)-2-methylpiperazine (109-07-9) → 3-methyl-1-(5-trifluoromethyl-pyridin-2-yl)-piperazine (866785-24-2)

Conditions	Yield
With triethylamine In toluene at 150℃; for 20h;	96%

Upstream product

• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 33252-63-0 5-(trifluoromethyl)-2(1H)-pyridone 
• 10026-13-8 phosphorus pentachloride 
• 2926-29-6 Langlois reagent 
• 444120-91-6 6-chloropyridin-3-ylboronic acid 
• 3796-23-4 3-(trifluoromethyl)pyridine 
• 108-99-6 3-Methylpyridine 
• 261956-65-4 2-chloro-5-trifluoromethylpyridine 1-oxide 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 69045-79-0 2-choro-5-iodopyridine 
• 1214756-50-9 2-cyclopropyl-1-(trifluoromethyl)benzo[b]thiophenium triflate 
• 22253-72-1 3-(trifluoromethyl)pyridine-N-oxide 
• 120120-26-5 (trifluoromethyl)triethylsilane 
• 33252-63-0 2-hydroxy-5-(trifluoromethyl)pyridine 

Downstream Products

• 136539-99-6 N,N-dimethyl-5-(trifluoromethyl)pyridine-2-amine 
• 372122-65-1 1-(3-chloro-4-fluorophenyl)-2-(5-trifluoromethyl-2-pyridinyl)ethanone oxime 
• 888739-99-9 4-(methoxymethoxy)-2-{[5-(trifluoromethyl)pyridine-2-yl]oxy}benzaldehyde 
• 100366-75-4 2‐iodo‐5‐(trifluoromethyl)pyridine 
• 252938-36-6 {5-imidazol-2-yl-4-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl}(2-{[5-(trifluoromethyl)(2-pyridyl)]amino}ethyl)amine 
• 252938-38-8 [4-(2,4-dichlorophenyl)-5-(1-methylimidazol-2-yl)pyrimidin-2-yl](2-{[5-(trifluoromethyl)(2-pyridyl)]amino }ethyl)amine 
• 252938-55-9 [4-(4-chloro-2-methylphenyl)-5-imidazol-2-ylpyrimidin-2-yl](2-{[5-(trifluoromethyl)(2-pyridyl)]amino}ethyl)amine 
• 173303-24-7 2-(5-trifluoromethyl-2-pyridyloxy)phenyl 2-oxazolin-2-yl ketone O-methyloxime 
• 31181-54-1 2-Methyl-5-(trifluoromethyl)pyridine 
• 71422-81-6 4-((5-(trifluoromethyl)pyridin-2-yl)oxy)aniline 
• 69045-85-8 2-(4-hydroxyphenoxy)-5-trifluoromethylpyridine 
• 944774-27-0 2-(4-chlorophenoxy)-5-trifluoromethylpyridine 
• 69045-89-2 2-(4'-hydroxyphenoxy)-3-chloro-5-trifluoromethylpyridine 
• 888739-90-0 3-(2-isopropoxy-4-{[5-(trifluoromethyl)pyridine-2-yl]oxy}phenyl)propanoic acid methyl ester 

Relevant articles and documents

METHOD FOR PREPARING 2,3-DICHLORO-5-TRIFLUOROMETHYLPYRIDINE WITH HIGH SELECTIVITY

The present invention discloses a method for preparing 2,3-dichloro-5-trifluoromethylpyridine, comprising at a temperature of 100?150° C. and a pressure of 0.5?5.0 MP, in presence of at least one catalyst selected from supported metal chloride, supported zeolite molecular sieve and supported heteropolyacid, 2-chloro-5-trifluoromethylpyridine reacts with chlorine gas to obtain 2,3-dichloro-5-trifluoromethylpyridine. The preparing method provided by the present invention has advantages such as high selectivity of desired product, high utilization rate of chlorine gas, moderate process condition, simple operation and less three wastes. The present invention also discloses a preparing method for preparing 2-chloro-5-trifluoromethylpyridine, which is capable of reducing unit consumption, reducing separation cost, and improving safety compared to the prior art.

METHOD FOR SEPARATING AND PURIFYING 2-CHLORO-3-TRIFLUOROMETHYLPYRIDINE

A method for separating and purifying 2-chloro-3-trifluoromethylpyridine useful as an intermediate for medicines, agrochemicals, and the like is provided. The method includes: 1) in the process of producing chloro β-trifluoromethylpyridine compounds by allowing a β-methylpyridine compound to react with chlorine and hydrogen fluoride in a reaction apparatus, allowing a β-trifluoromethylpyridine compound to react with chlorine in a reaction apparatus, or allowing a chloro β-trichloromethylpyridine compound to react with hydrogen fluoride in a reaction apparatus,2) fractionating a liquid mixture containing chloro β-trifluoromethylpyridine compounds from the reaction apparatus, and3) separating and purifying 2-chloro-3-trifluoromethylpyridine from the liquid mixture.

Preparation method of 2-cholrine-5-trifluoromethyl pyridine

The invention discloses a preparation method of 2-cholrine-5-trifluoromethyl pyridine. The method comprises the following steps of 1, adding a raw material 2-cholrine-5-methyl fluoride pyridine into a reaction kettle, and then adding thionyl chloride; 2, raising the temperature, and introducing chlorine into the reaction kettle; 3, after introduction of chlorine is ended, transferring the raw material into a fluorination kettle; 4, adding hydrogen fluoride which is measured well into the fluorination kettle, adding anhydrous hydrogen fluoride, raising the temperature, and conducting a reaction; 5, conducing washing and water vapor distillation on a fluoridation material, adjusting the pH value, and conducting distillation in a pressing-in rectifying tower, so that 2-cholrine-5-trifluoromethyl pyridine is obtained. According to the preparation method, thionyl chloride is adopted as solvent, so that the problem that the material contains water is solved; meanwhile, low-temperature chlorination is adopted for producing the 2-cholrine-5-trifluoromethyl pyridine chlorination material, and the foundation is laid for preparing high-purity 2-cholrine-5-trifluoromethyl pyridine.