52334-92-6

Basic information

• Product Name: 2-(DIMETHYLAMINO)ACETALDEHYDE
• Synonyms: 2-(DIMETHYLAMINO)ACETALDEHYDE;Acetaldehyde, 2-(dimethylamino)-;2-(DIMETHYLAMINO)ACETALDEHYDE(Bisulfite form)
• CAS NO: 52334-92-6
• Molecular Formula: C₄H₉NO
• Molecular Weight: 87.12036
• EINECS: -0
• Mol File: 52334-92-6.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 87.5±23.0 °C(Predicted)
• Appearance: /
• Density: 0.878±0.06 g/cm3(Predicted)
• PKA: 7.61±0.28(Predicted)
• CAS DataBase Reference: 2-(DIMETHYLAMINO)ACETALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(DIMETHYLAMINO)ACETALDEHYDE(52334-92-6)
• EPA Substance Registry System: 2-(DIMETHYLAMINO)ACETALDEHYDE(52334-92-6)

Safety Data

• Hazardous Substances Data: 52334-92-6(Hazardous Substances Data)

Usage

General Description

2-(Dimethylamino)acetaldehyde is a chemical compound with the molecular formula C5H11NO. It is a colorless liquid with a strong, pungent odor and is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. This chemical is also utilized as a reagent in the formation of complex organic molecules and has various industrial applications. It is important to handle this compound with caution as it can be harmful if ingested, inhaled, or in contact with the skin or eyes. Additionally, it should be stored and used in a well-ventilated area with appropriate protective equipment to ensure the safety of those working with it.

Upstream product

• 38711-20-5 1,1-dimethoxymethyl-N,N-dimethylmethanamine 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 3616-56-6 dimethylaminoacetaldehyde diethyl acetal 

Downstream Products

• 944915-61-1 C₂₀H₂₃FN₄O 
• 1680184-59-1 4-[(3-chloro-4-fluorophenyl)amino]-6-{[4-(N,N-dimethylamino)-1-oxo-2-buten-1-yl]amino}-7-[(S)-(tetrahydrothran-3-yl)oxy]quinazoline 
• 2135696-72-7 (E)-N-(4-((3-bromo-4-chlorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)-4-(dimethylamino)but-2-enamide 
• 698387-09-6 neratinib 
• 6711-46-2 N,N-dimethyl-N'-phenyl-1,2-ethanediamine 
• 1422356-88-4 (3aR,5aR,5bR,7aR,9S,11aR,11bR,13aS)-3a-(2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)acetyl)-9-hydroxy-1-isopropyl-5a,5b,8,8,11a-pentamethyl-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2H-cyclopenta[a]chrysen-2-one 
• 52334-50-6 2-[3-(2-dimethylaminoethyl)aminophenyl]oxazolo[4,5-b]pyridine 

Relevant articles and documents

Preparation method of quinazolinyl butylene amide compound

The invention discloses a preparation method of a quinazolinyl butylene amide compound, which effectively reduces the generation of impurities in the synthesis process by selecting a proper mixed alkali system and using a mixture of 1, 5-diaza-bicyclo [4.3. 0] nonyl-5-ene and potassium hydroxide, avoids the additional generation of degraded impurities in the medicine storage process, and accurate control over impurity generation and degradation is achieved.

Substituted quinoline-8-carbonitrile derivatives having androgen receptor degradation activity and uses thereof

The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. In some embodiments, the compounds disclosed herein exhibit androgen receptor degradation activity.

Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing 2,3-dihydro-indole or 1,2,3,4-tetrahydroquinoline as potential EGFR inhibitors

Eight series of quinazoline derivatives bearing 2,3-dihydro-indole or 1,2,3,4-tetrahydroquinoline were designed, synthesized and evaluated for the IC50 values against three cancer cell lines (A549, MCF-7 and PC-3). Most of the forty nine target compounds showed excellent antiproliferative activity against one or several cancer cell lines. The compound 13a showed the best activity against A549, MCF-7 and PC-3 cancer cell lines, with the IC50 values of 1.09 ± 0.04 μM, 1.34 ± 0.13 μM and 1.23 ± 0.09 μM, respectively. Eight selected compounds were further selected to evaluated for the inhibitory activity against EGFR kinase. Three of them showed equal activity against EGFR kinase to positive control afatinib. AnnexinV-FITC, propidium iodide (PI) double staining and acridine orange single staining results indicated that the compound 13a could induce apoptosis of human lung cancer A549 cells.