52346-15-3Relevant academic research and scientific papers
A novel, stereoselective synthesis of cis-4a(S), 8a(R)-decahydro-6(2H)-isoquinolones from meroquinene esters
Martinelli,Peterson,Khau,Hutchison,Sullivan
, p. 5413 - 5416 (1993)
Intramolecular cyclization of N-acylated meroquinene t-butyl esters in cold H2SO4 cleanly afforded cis-4a(S), 8a(R)-decahydro-6(2H)-isoquinolones with complete stereocontrol in >95% yield. Formation of the meroquinene esters from cinchona alkaloid autoxidation using an improved Doering protocol was accomplished in three steps with 85% overall yield.
