5236-87-3

Usage

Uses

Used in Pharmaceutical Industry:
8-Chloro-2-methyl-4-quinolinol is used as an intermediate in the synthesis of various drugs, leveraging its unique chemical properties and potential biological activity to contribute to the development of new medicinal compounds.
Used in Pesticide Production:
8-CHLORO-2-METHYL-4-QUINOLINOL is also utilized in the production of pesticides, where its reactivity and stability play a crucial role in creating effective and long-lasting formulations for agricultural and other applications.
Used in Organic Synthesis:
8-Chloro-2-methyl-4-quinolinol serves as a key intermediate in organic synthesis, enabling the creation of a wide range of organic compounds for various industrial applications, including the development of new materials and chemical processes.

InChI:InChI=1/C10H8ClNO/c1-6-5-9(13)7-3-2-4-8(11)10(7)12-6/h2-5H,1H3,(H,12,13)

Upstream product

• 42792-92-7 3-(2-chloro-anilino)-trans-crotonic acid ethyl ester 
• 141-97-9 ethyl acetoacetate 
• 95-51-2 o-chloroaniline 
• 872496-78-1 C₁₂H₁₄ClNO₂ 

Downstream Products

• 1263193-21-0 2-chloro-6-(3-methyl-1H-pyrazol-5-yl)aniline 
• 75896-69-4 4,8-dichloro-2-methylquinoline 

Relevant academic research and scientific papers

Microwave-assisted Synthesis of 2-methyl-4-quinolinones via combes synthesis catalyzed by acidic resin under solvent-free condition

A simple and efficient method for the synthesis of 2-methylquinolin-4(1H)- one derivatives using NKC-9-resin as reusable eco-friendly catalyst via Combes cyclization under solvent-free and microwave irradiation conditions is described. The quinolines were obtained in high yields and in short reaction times.

NaHSO4/SiO2: An efficient catalyst for the synthesis of β-enaminones and 2-methylquinolin-4(1H)-ones under solvent-free condition

An efficient and simplified protocol for NaHSO4/SiO2 catalyzed solvent-free synthesis of β-enaminone and 2-methylquinolin-4(1H)- one derivatives under microwave irradiation is described. A series of functionalized derivatives have been synthesized in shorter reaction times with moderate to good yields. The use of milder catalyst in non-conventional method offers significant advantages over conventional methods, such as higher selectivities, simplicity, solvent-free reaction and non-environmental polluting conditions.

Hepatitis C inhibitor peptide analogs

Compounds of formula (I): wherein R1, R2, R3, R4, R5, Y, n and m are as defined herein. The compounds are useful as inhibitors of HCV NS3 protease.

HEPATITIS C INHIBITOR PEPTIDE ANALOGS

The invention relates to compounds of formula (I) wherein R', R2, R3, R4, R5, R6, Y, n and m are as defined herein. The compounds are useful for the treatment and prevention of hepatitis C viral infections in mammals by inhibiting HCV NS3 protease. The invention further relates to azalactone compounds of the formula (III) which can be reacted with an amide anion to produce the compounds of formula (I).