52370-58-8

Usage

InChI:InChI=1/C14H18N2O7/c15-8(13(20)21)2-4-12(19)16-9(14(22)23)5-7-1-3-10(17)11(18)6-7/h1,3,6,8-9,17-18H,2,4-5,15H2,(H,16,19)(H,20,21)(H,22,23)

Upstream product

• 56-85-9 L-glutamine 
• 59-92-7 levodopa 
• 70-18-8 GLUTATHIONE 

Relevant academic research and scientific papers

Synthesis of γ-Glutamyl L-3,4-Dihydroxyphenylalanine by γ-Glutamyltranspeptidase from Proteus mirabilis

Synthesis of γ-glutamyl-L-3,4-dihydroxyphenylalanine from a γ-glutamyl donor (glutathione or glutamine) and DOPA (L-3,4-dihydroxyphenylalanine) was examined making use of the partially purified γ-glutamyltranspeptidase from a bacterium, Proteus mirabilis.The optimum pH for γ-glutamyl-DOPA synthesis from glutathione was 9.5 to 11 and the amount of peptide produced increased with the glutathione concentration.The best conditions for γ-glutamyl -DOPA synthesis were investigated and 13 mg/ml of γ-glutamyl-DOPA was synthesized with a yield of 6,7percent of the substrate,glutathione.The product was isolated from a large scale reaction mixture and the sructure determined by physicochemical analyses; PMR spectrometry, mass spectrometry and IR spectrometry,γ-Glutamyl-DOPA synthesis was also performed with glutamine as the γ-glutamyl donor.