52372-97-1

Basic information

• Product Name: 5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-aMine
• Synonyms: 5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-aMine;(5-Methoxytetralin-1-yl)amine;1,2,3,4-Tetrahydro-5-methoxy-1-naphthalenamine;5-Methoxy-1-tetralinamine
• CAS NO: 52372-97-1
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.2429
• Mol File: 52372-97-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 22-25℃
• Boiling Point: 298.1°Cat760mmHg
• Flash Point: 138.5°C
• Appearance: /
• Density: 1.056g/cm³
• Vapor Pressure: 0.0013mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-aMine(52372-97-1)
• EPA Substance Registry System: 5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-aMine(52372-97-1)

Safety Data

• Hazardous Substances Data: 52372-97-1(Hazardous Substances Data)

Usage

General Description

5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-amine, also known as 5-MeO-NaPT, is a chemical compound belonging to the class of substituted amphetamines. It is a hallucinogenic and psychoactive substance that acts as a serotonin receptor agonist. 5-MeO-NaPT is known to produce psychedelic effects similar to those of other hallucinogens, such as visual and auditory distortions, altered perception of time and space, and changes in mood and consciousness. It is considered a designer drug and has been subject to legal restrictions in several countries due to its potential for abuse and harmful health effects. The compound is often consumed for recreational purposes, but its use is associated with significant risks and potential adverse reactions, making it a substance of concern in the context of public health and safety.

InChI:InChI=1/C11H15NO/c1-13-11-7-3-4-8-9(11)5-2-6-10(8)12/h3-4,7,10H,2,5-6,12H2,1H3

Upstream product

• 52372-99-3 N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)benzylamine 
• 30069-58-0 5-methoxy-3,4-dihydro-2H-naphthalen-1-one oxime 
• 872539-36-1 (Z)-5-methoxy-3,4-dihydronaphthalen-1(2H)-one oxime 
• 33892-75-0 5-Methoxy-1-tetralone 

Downstream Products

• 1426537-95-2 benzyl N-(5-methoxy-1,2,3,4-tetrahydronaphthalene-1-yl)sulfamoylcarbamate 
• 103882-27-5 (R)-(-)-5-methoxy-1,2,3,4-tetrahydro-1-naphthalenamine 

Relevant articles and documents

MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF

The disclosure relates to compounds and pharmaceutical compositions capable of modulating the hydroxysteroid 17-beta dehydrogenase (HSD17B) family member proteins including inhibiting the HSD17B member proteins, e.g. HSD17B13. The disclosure further relates to methods of treating liver diseases, disorders, or conditions with the compounds and pharmaceutical compositions disclosed herein, in which the HSD17B family member protein plays a role.

Preparation of optical homochiral amine

The invention discloses a preparation method of an optical homochiral amine R-5-methoxy-1-naphthalenamine. The method concretely comprises the following steps: carrying out reducing ammonification on a raw material 5-methoxy-1-tetralone to obtain rac-5-methoxy-1-tetralone, and carrying out enzyme-catalyzed dynamic kinetic resolution on the above racemic amine to obtain R-5-methoxy-1-naphthalenamine. The method has the characteristics of simplicity in operation, easily available raw materials, and realization of good yield and high optical purity of the above product.

PYRIMIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE

The present invention provides compounds of Formula (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.