52379-96-1

Usage

Composition

Theophylline molecule with a thiol group (sulfanyl) attached and an acetamide group.

Source

Theophylline is a naturally occurring compound found in tea and coffee.

Medical use

Treats respiratory conditions such as asthma and chronic obstructive pulmonary disease.

Advantages

The addition of the acetamide group enhances solubility and bioavailability, making it a more effective drug in treating pulmonary conditions.

Industry value

Valuable in the pharmaceutical industry for the development of respiratory medications.

Relevant academic research and scientific papers

Purines useful for the potentiation of antibiotics

Purines useful for the potentiation of antibiotics, particularly phleomycin and bleomycin, have the general formula: STR1 wherein W is selected from the group consisting of --SRCONR1 R2, --SRCN, and --SRCOR1, in which R is a --(CH2)n -- group (n is an integer of 1 to 5) which may bear one or more side chain alkyl groups each having from 1 to 5 carbon atoms, and R1 and R2, which may be the same or different, are selected from hydrogen atoms and straight or branched chain alkyl groups having from 1 to 5 carbon atoms, or alternatively, R1 and R2 together comprise a polymethylene, oxapolymethylene or thiapolymethylene chain containing from 4 to 10 carbon atoms; R3, R4, R5 and R6, which may be the same or different, are selected from hydrogen atoms and straight or branched chain alkyl groups having from 1 to 5 carbon atoms; and R, R1, R2, R3, R4, R5 and R6 may be substituted by one or more non-toxic substituents.