52395-03-6Relevant academic research and scientific papers
Reactions of hydroxyglycines. New synthetic routes to 4-phenylquinazoline derivatives
Hoefnagel,Van Koningsveld,Van Meurs,Peters,Sinnema,Van Bekkum
, p. 6899 - 6912 (2007/10/02)
Reaction of hydroxyglycine with 2-aminobenzophenones gives 1,2-dihydro-4-phenyl-quinazoline-2-carboxylic acids in high yields and under mild conditions. These can be smoothly converted into the corresponding 3,4-dihydro isomers and into quinazoline derivatives via rearrangement and oxidation by air, respectively. The X-ray crystallographic structure of 6-chloro-1,2-dihydro-1-methyl-4-phenylquinazoline-2-carboxylic acid shows the carboxylate group at C(2) and the methyl group at N(1) to be in axial positions.
