523987-55-5

Upstream product

• 207223-19-6 2S,5S,6R-2,4,5-trimethyl-2-hydroxy-6-phenyl-morpholin-3-one 
• 523987-62-4 (3S,4R,2'S,5'S,6'R)-1,4-di-(4-methoxyphenyl)-3-[(2',4',5'-trimethyl-3'-oxo-6'-phenylmorpholin-2'-yl)oxy]azetidin-2-one 
• 523987-57-7 ethyl (2S,5S,6R)-[(2,4,6-trimethyl-3-oxo-6-phenylmorpholin-2-yl)oxy]acetate 

Downstream Products

• 146924-94-9 (3R,4S)-(+)-3-hydroxy-1-(4-methoxyphenyl)-4-phenyl-2-azetidinone 
• 207223-19-6 2S,5S,6R-2,4,5-trimethyl-2-hydroxy-6-phenyl-morpholin-3-one 

Relevant academic research and scientific papers

Ephedrine derived reusable chiral auxiliary for the synthesis of optically pure 3-hydroxy-4-aryl-β-lactams

The diastereoselective synthesis of various β-lactams has been achieved using a chiral acid auxiliary derived from (-)-ephedrine. An efficient acid-catalyzed cleavage of the chiral auxiliary from these β-lactams to afford 3-hydroxy-4-aryl-cis-β-lactams, which are precursors for analogues of the taxol side chain, is described.