524018-13-1Relevant articles and documents
Synthesis of 2,4,5-trisubstituted tetrahydropyrans as peptidomimetic scaffolds for melanocortin receptor ligands.
Kulesza, Anna,Ebetino, Frank H,Mishra, Rajesh K,Cross-Doersen, Doreen,Mazur, Adam W
, p. 1163 - 1166 (2007/10/03)
[reaction: see text] We have synthesized a series of 2,4,5-trisubstituted tetrahydropyran derivatives to determine the utility of this scaffold as a peptidomimetic platform. The key synthetic steps involved a palladium-mediated cross-coupling reaction of