524019-24-7Relevant academic research and scientific papers
Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety
Yang, Shu-Wei,Ho, Ginny,Tulshian, Deen,Greenlee, William J.,Tan, Zheng,Zhang, Hongtao,Smith-Torhan, April,Fawzi, Ahmad,Anthes, John,Lu, Sherry,Varty, Geoffrey,Fernandez, Xiomara,McLeod, Robbie L.,Hey, John
scheme or table, p. 2482 - 2486 (2009/12/25)
A series of nortropane analogs based on previously reported compound 1 have been synthesized and shown to bind to the nociceptin receptor with high affinity. The synthesis and structure-activity relationships around the C-3 nortropane substitution are des
Process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols
-
Page/Page column 7, (2010/10/20)
The present invention relates to a process for preparing substituted 8-azabicyclo[3.2.1]octan-3-ols having the structural formula I or a pharmaceutically acceptable salt or solvate thereof, wherein R is benzyl, R5-benzyl, allyl, —C(O)R6, —C(O)OR8 or —CH(R7)2; R1 is optionally substituted aryl or optionally substituted heteroaryl; and R5, R6, R7 and R8 are as defined in the specification; comprising a) reacting an amine of formula II [in-line-formulae]R—NH2??II [/in-line-formulae] with 2,5-dimethoxytetrahydrofuran or HC(O)(CH2)2C(O)H, and C(O)(CH2C(O)OR4)2, wherein R4 is H or alkyl, to obtain a compound of formula III b) reacting a compound of formula III with I-R1, alkyl lithium, and optionally a lithium salt, to obtain a compound of formula I; and c) optionally converting a compound of formula I wherein R is benzyl, R5-benzyl, allyl, —C(O)R6 or —C(O)OR6 to a compound of formula I wherein R is —CH(R7)2. Intermediates in the process are also claimed.
