52402-00-3Relevant academic research and scientific papers
Improved stability of proline-derived direct thrombin inhibitors through hydroxyl to heterocycle replacement
Chobanian, Harry R.,Pio, Barbara,Guo, Yan,Shen, Hong,Huffman, Mark A.,Madeira, Maria,Salituro, Gino,Terebetski, Jenna L.,Ormes, James,Jochnowitz, Nina,Hoos, Lizbeth,Zhou, Yuchen,Lewis, Dale,Hawes, Brian,Mitnaul, Lyndon,O'Neill, Kim,Ellsworth, Kenneth,Wang, Liangsu,Biftu, Tesfaye,Duffy, Joseph L.
, p. 553 - 557 (2015/05/27)
Modification of the previously disclosed (S)-N-(2-(aminomethyl)-5-chlorobenzyl)-1-((R)-2-hydroxy-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamide 2 by optimization of the P3 group afforded novel, low molecular weight thrombin inhibitors. Heterocycle replace
Cis-platinum-diamine complexes and antitumorous compositions containing them, and process for their preparation
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, (2008/06/13)
The present invention relates to novel cis-platinumdiamine complexes represented by the general formula (I) and the process of preparation thereof. The definitions of the substituents in the above-mentioned formula are the same as defined in the specification. The present invention also provides antitumorous compositions containing one or more of the above-said complexes as active ingredients. STR1
