52403-77-7

Basic information

• Product Name: Ethanone, 1-(2-methyl-4-phenyl-3-furanyl)-
• CAS NO: 52403-77-7
• Molecular Formula: C13H12O2
• Molecular Weight: 200.237
• Mol File: 52403-77-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(2-methyl-4-phenyl-3-furanyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-methyl-4-phenyl-3-furanyl)-(52403-77-7)
• EPA Substance Registry System: Ethanone, 1-(2-methyl-4-phenyl-3-furanyl)-(52403-77-7)

Safety Data

• Hazardous Substances Data: 52403-77-7(Hazardous Substances Data)

Upstream product

• 123-54-6 acetylacetone 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 72709-61-6 (+/-)-3-(2-nitro-1-phenylethyl)pentane-2,4-dione 

Relevant articles and documents

Silylation of γ-nitro ketones as a convenient approach to the synthesis of 2-[N,N-bis(silyloxy)amino]-2,3-dihydrofurans and conjugated enoximes

Silylation of γ-nitro ketones of the general formula R 1COCH(R2)CH(R3)CH(R4)NO2 proceeded stereoselectively to give 2-[N,N-bis(trimethylsilyloxy)amino]-2,3- dihydrofurans, conjugated enoximes, silylation products of the carbonyl group or both functional groups, or N,N-bis(trimethylsilyloxy)enamine depending on the nature and positions of the substituents in the carbon skeleton. Dihydrofuran derivatives are formed for R1 = Ar or cyclo-C 3H5. Enoximes are generated as the silylation products of the starting ketones with enhanced β-proton mobility (R3 = CO2Me or 4-NO2C6H4). The presence of an alkyl group at the carbonyl function (R1 = Alk) is favorable for the formation of enoximes. Finally, the introduction of a substituent at the α position with respect to the nitro group (R4 = Me, CO2Me, or Ph) leads to the formation of silyl enolates. Under the action of NH4F in MeOH, dihydrofurans can be transformed into substituted furans in moderate yields.