5241-24-7Relevant academic research and scientific papers
Novel approach to determining the absolute configurations at the C3-positions of various types of sterols based on an induced circular dichroism
Fujiwara, Toshio,Taniguchi, Yuka,Katsumoto, Yukiteru,Tanaka, Takeyuki,Ozeki, Minoru,Iwasaki, Hiroki,Node, Manabu,Yamashita, Masayuki,Hosoi, Shinzo
, p. 1198 - 1204 (2012/11/07)
Circular dichroism (CD) spectra of the 2,2′-binaphthyl ester derived from Δ5-sterols showed not bisignate CD but diagnostic CD bands at around 210 and 240 nm. These bands might be attributable to an interaction between an olefinic chromophore and a binaphthyl one. Various types of unsaturated sterols were thus derivatized followed by complete hydrogenation, to give saturated sterols. As a result, CD spectra of the binaphthyl derivatives of the saturated sterols showed bisignate curves centered at 240 nm (3S(β): positive chirality; 3R(α): negative one). This suggested a straightforward and practical method for discriminating the absolute stereogenic center at the C-3 positions of sterols based on an induced CD. This finding should contribute significantly to the analysis of metabolites of various types of sterols.
Ammonium formate/palladium on carbon: A versatile system for catalytic hydrogen transfer reductions of carbon-carbon double bonds
Paryzek, Zdzislaw,Koenig, Hanna,Tabaczka, Bartlomiej
, p. 2023 - 2026 (2007/10/03)
Various carbon-carbon double bonds in olefins and α,β -unsaturated ketones were effectively reduced to the corresponding alkanes and saturated ketones, using ammonium formate as a hydrogen transfer agent in the presence of Pd/C as catalyst in refluxing methanol.
