52413-92-0

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 5039-16-7 2-chloro-N-(phenylthiazol-2-yl)acetamide 
• 70-11-1 α-bromoacetophenone 
• 2010-06-2 2-Amino-4-phenylthiazole 

Downstream Products

• 52471-12-2 5-(2-chlorobenzylidene)-2-(4-phenyl-1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-one 
• 52413-95-3 5-(4-nitro-benzylidene)-2-(4-phenyl-thiazol-2-ylamino)-thiazol-4-one 
• 52413-94-2 5-(4-methoxy-benzylidene)-2-(4-phenyl-thiazol-2-ylamino)-thiazol-4-one 
• 52413-96-4 5-(2-hydroxy-benzylidene)-2-(4-phenyl-thiazol-2-ylamino)-thiazol-4-one 
• 52471-11-1 5-(2-nitro-benzylidene)-2-(4-phenyl-thiazol-2-ylamino)-thiazol-4-one 
• 52414-08-1 5-bromo-5-[bromo-(2-chloro-phenyl)-methyl]-2-(4-phenyl-thiazol-2-ylamino)-thiazol-4-one 
• 52414-05-8 5-bromo-5-[bromo-(4-methoxy-phenyl)-methyl]-2-(4-phenyl-thiazol-2-ylamino)-thiazol-4-one 
• 52414-06-9 5-bromo-5-[bromo-(4-nitro-phenyl)-methyl]-2-(4-phenyl-thiazol-2-ylamino)-thiazol-4-one 
• 52414-07-0 5-bromo-5-[bromo-(2-nitro-phenyl)-methyl]-2-(4-phenyl-thiazol-2-ylamino)-thiazol-4-one 
• 1056198-93-6 5-(4-hydroxy-3-methoxybenzylidene)-2-(4-phenylthiazol-2-ylimino)thiazolidin-4-one 
• 1401514-02-0 (5Z)-5-((5-nitrothiophen-2-yl)methylene)-2-(4-phenylthiazol-2-ylimino)thiazolidin-4-one 
• 1401514-06-4 (5Z)-5-((1-methyl-5-nitro-1H-imidazol-2-yl)methylene)-2-(4-phenylthiazol-2-ylimino)thiazolidin-4-one 
• 1416588-20-9 5-(4-chlorobenzylidene)-2-(4-phenyl-1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-one 
• 52413-93-1 5-(benzylidene)-2-(4-phenyl-1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-one 

Relevant academic research and scientific papers

Synthesis of New Binary Thiazole-Based Heterocycles and Their Molecular Docking Study as COVID-19 Main Protease (Mpro) Inhibitors

Abstract: Isolated polynuclear binary heterocyclic compounds containing thiazole building block combined with benzofuran, pyrrole, thiazole, or thiophene via carboxamide and/or secondary amine as a junction are presented. The synthetic strategy of those is based on utilization of 2-chloroacetamido-4-phenylthiazole in the synthesis of binary heterocyclic compounds by cyclocondensation with salicylic aldehyde, acetonitrile derivatives, ammonium thiocyanate, 3-mercaptoacrylonitrile derivatives, and/or 3-mercaptoacrylate derivatives. The prepared binary thiazole-based heterocycles have been studied as protease (Mpro) inhibitors by molecular docking for visualization of their orientation and interactions with COVID-19 units using hydroxychloroquine as a reference molecule.

5-Nitro-heteroarylidene analogs of 2-thiazolylimino-4-thiazolidinones as a novel series of antibacterial agents

In the pursuit of novel antibacterial agents with the 2-thiazolylimino-4- thiazolidinone as a core structure, a series of 5-nitro-heteroarylidene and 5-(2-oxoindolin-3-ylidene) analogs of 2-thiazolylimino-5-arylidene-4- thiazolidinone were synthesized and their antibacterial activities were evaluated against some strains of Gram-positive and Gram-negative bacteria, as well as Helicobacter pylori strains. Biological data indicated that 5-nitrofuran analog 5a and 5-nitroimidazole analog 7a containing no substitutions on the thiazole ring were the most potent compounds.

Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2- ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents

As a part of our ongoing studies in developing new derivatives as dual antimicrobial/anti-inflammatory agents we describe the synthesis of novel 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones. All newly synthesized compounds were tested for

2-thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action

SHP-2, a nonreceptor protein tyrosine phosphatase encoded by the PTPN11 gene, mediates cell signaling by growth factors and cytokines via the RAS/MAP kinase pathway. Somatic mutations in PTPN11 gene account for approximately 18% of juvenile myelomonocytic