52417-04-6

Basic information

• Product Name: 9-[5-O-acetyl-2,3-O-(1-methylethylidene)pentofuranosyl]-2-amino-3,9-dihydro-6H-purin-6-one
• CAS NO: 52417-04-6
• Molecular Formula: C₁₅H₁₉N₅O₆
• Molecular Weight: 365.3413
• Mol File: 52417-04-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 628.8°C at 760 mmHg
• Flash Point: 334.1°C
• Density: 1.78g/cm³
• Vapor Pressure: 1E-15mmHg at 25°C
• Refractive Index: 1.752
• CAS DataBase Reference: 9-[5-O-acetyl-2,3-O-(1-methylethylidene)pentofuranosyl]-2-amino-3,9-dihydro-6H-purin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-[5-O-acetyl-2,3-O-(1-methylethylidene)pentofuranosyl]-2-amino-3,9-dihydro-6H-purin-6-one(52417-04-6)
• EPA Substance Registry System: 9-[5-O-acetyl-2,3-O-(1-methylethylidene)pentofuranosyl]-2-amino-3,9-dihydro-6H-purin-6-one(52417-04-6)

Safety Data

• Hazardous Substances Data: 52417-04-6(Hazardous Substances Data)

Upstream product

• 1184784-60-8 5'-O-bromoisobutyryl-2',3'-O-isopropylidene guanosine 
• 108-24-7 acetic anhydride 
• 362-76-5 2',3'-isopropylideneguanosine 

Relevant articles and documents

Protection of the amino group of adenosine and guanosine derivatives by elaboration into a 2,5-dimethylpyrrole moiety

(Matrix presented) Protection of the amino group of adenine and guanine nucleosides was effected by heating the substrates in 2,5-hexanedione. The resulting 2,5-dimethylpyrrole adducts were stable toward bases but were hydrolyzed with TFA/H2O to regenerate the amino function.

Pyridine-free and solvent-free acetylation of nucleosides promoted by molecular sieves

A practical method for the acetylation of purine and pyrimidine nucleosides employing a combination of acetic anhydride and potassium-exchanged molecular sieves is described. Besides the high yields obtained for the acylated nucleosides, the procedure is simple, inexpensive and environmentally benign, avoiding the use of pyridine or co-solvents as additives. Georg Thieme Verlag Stuttgart.