52422-54-5Relevant academic research and scientific papers
Towards targeting anticancer drugs: Ruthenium(II)-arene complexes with biologically active naphthoquinone-derived ligand systems
Kubanik, Mario,Kandioller, Wolfgang,Kim, Kunwoo,Anderson, Robert F.,Klapproth, Erik,Jakupec, Michael A.,Roller, Alexander,S?hnel, Tilo,Keppler, Bernhard K.,Hartinger, Christian G.
, p. 13091 - 13103 (2016/09/04)
Anticancer active metal complexes with biologically active ligands have the potential to interact with more than one biological target, which could help to overcome acquired and/or intrinsic resistance of tumors to small molecule drugs. In this paper we present the preparation of 2-hydroxy-[1,4]-naphthoquinone-derived ligands and their coordination to a RuII(η6-p-cymene)Cl moiety. The synthesis of oxime derivatives resulted in the surprising formation of nitroso-naphthalene complexes, as confirmed by X-ray diffraction analysis. The compounds were shown to be stable in aqueous solution but reacted with glutathione and ascorbic acid rather than undergoing reduction. One-electron reduction with pulse radiolysis revealed different behavior for the naphthoquinone and nitroso-naphthalene complexes, which was also observed in in vitro anticancer assays.
PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND PREVENTION OF DISEASES INVOLVING IMPOTENCE
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, (2008/12/06)
Disclosed is a pharmaceutical composition for the treatment and/or prevention of erectile dysfunction, comprising (a) a therapeutically effective amount of a compound represented by Formula 1 or 2, and (b) a pharmaceutically acceptable carrier, a diluent or an excipient, or any combination thereof.
Palladium-catalyzed allylation of 2-hydroxy-1,4-naphthoquinone: Application to the preparation of lapachol
Kazantzi, Georgia,Malamidou-Xenikaki, Elizabeth,Spyroudis, Spyros
, p. 427 - 430 (2008/01/03)
The Pd(PPh3)4-catalyzed reaction of 2-hydroxy-1,4-naphthoquinone (lawsone) with allyl alcohols and allyl esters offers an easy access to 3-allyl-2-hydroxy-1,4-naphthoquinones, compounds with interesting biological activity. The reaction finds application in the preparation of lapachol. Other 2-hydroxy-1,4-benzoquinones give allylation products in low yields. Georg Thieme Verlag Stuttgart.
Selenium reagent in the synthesis of naphtho[2,3-b]furan-4,9-diones
De Oliveira, Alaide Braga,Raslan, Delio Soares,Khuong-Huu, Francoise
, p. 6873 - 6876 (2007/10/02)
Phenylselenoetherification was used to synthezise naphtho[2,3-b]furan-4,9-diones and naphtho[2,3-b]pyran-5,10-diones from 2-hydroxynaphthoquinones.
