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52427-05-1

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52427-05-1 Usage

General Description

2-Bromo-4-nitrophenol is a chemical compound with the molecular formula C6H4BrNO3. It is a yellow crystalline solid that is primarily used as a precursor for the synthesis of pharmaceuticals, dyes, and other organic compounds. It is also used as an intermediate in the production of agricultural chemicals and in the manufacturing of rubber and plastic. 2-Bromo-4-nitrophenol is classified as a hazardous substance and can cause irritation to the skin, eyes, and respiratory tract upon exposure. It is important to handle and store this chemical with caution and in accordance with safety guidelines.

Check Digit Verification of cas no

The CAS Registry Mumber 52427-05-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,4,2 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 52427-05:
(7*5)+(6*2)+(5*4)+(4*2)+(3*7)+(2*0)+(1*5)=101
101 % 10 = 1
So 52427-05-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H4BrNO3/c7-5-2-1-4(8(10)11)3-6(5)9/h1-3,9H

52427-05-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Bromo-5-nitrophenol

1.2 Other means of identification

Product number -
Other names Phenol,2-bromo-5-nitro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:52427-05-1 SDS

52427-05-1Relevant articles and documents

Quinolone-based compounds, formulations, and uses thereof

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Page/Page column 117, (2018/07/02)

Provided herein are quinolone-based compounds that can be used for treatment and/or prevention of malaria and formulations thereof. Also provided herein are methods of treating and/or preventing malaria in a subject by administering a quinolone-based compound or formulation thereof provided herein.

ICI 56,780 optimization: Structure-activity relationship studies of 7-(2-phenoxyethoxy)-4(1H)-quinolones with antimalarial activity

Maignan, Jordany R.,Lichorowic, Cynthia L.,Giarrusso, James,Blake, Lynn D.,Casandra, Debora,Mutka, Tina S.,LaCrue, Alexis N.,Burrows, Jeremy N.,Willis, Paul A.,Kyle, Dennis E.,Manetsch, Roman

, p. 6943 - 6960 (2016/08/05)

Though malaria mortality rates are down 48% globally since 2000, reported occurrences of resistance against current therapeutics threaten to reverse that progress. Recently, antimalarials that were once considered unsuitable therapeutic agents have been revisited to improve physicochemical properties and efficacy required for selection as a drug candidate. One such compound is 4(1H)-quinolone ICI 56,780, which is known to be a causal prophylactic that also displays blood schizonticidal activity against P. berghei. Rapid induction of parasite resistance, however, stalled its further development. We have completed a full structure-activity relationship study on 4(1H)-quinolones, focusing on the reduction of cross-resistance with atovaquone for activity against the clinical isolates W2 and TM90-C2B, as well as the improvement of microsomal stability. These studies revealed several frontrunner compounds with superb in vivo antimalarial activity. The best compounds were found to be curative with all mice surviving a Plasmodium berghei infection after 30 days.

4(1H)-Quinolones Having Antimalarial Activity With Reduced Chemical Resistance

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Paragraph 0226; 0227; 0228, (2013/05/22)

Provided are 4(1H)-quinolone derivatives effective in inhibiting or eliminating the viability of at least one of the stages in the life-cycle of the malarial parasite, and to show a reduced propensity to induce resistance to the compound by the target parasite. In particular, the compounds can be derivatives of phenoxyethoxy-quinolones, and including, but not only, 7-(2-phenoxyethoxy)quinolin derivatives. These compounds may be administered by themselves, with at least one other derivative compound, or with other antimalarial compounds, to an animal or human subject. The therapeutic compositions can be and formulated to reduce the extent of a Plasmodium infection in the recipient subject, or to reduce the likelihood of the onset or establishment of a Plasmodium infection if administered prior to the parasite contacting the subject. The therapeutic compositions can be formulated to provide an effective single dose amount of an antimalarial compound or multiple doses for administering over a period of time.

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