52431-59-1

Basic information

• Product Name: 5-chloro-8-hydroxynaphthalene-1,4-dione
• Synonyms: 1,4-naphthalenedione, 5-chloro-8-hydroxy-
• CAS NO: 52431-59-1
• Molecular Formula: C₁₀H₅ClO₃
• Molecular Weight: 208.5979
• Mol File: 52431-59-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 447.3°C at 760 mmHg
• Flash Point: 224.3°C
• Density: 1.569g/cm³
• Vapor Pressure: 1.29E-08mmHg at 25°C
• Refractive Index: 1.67
• CAS DataBase Reference: 5-chloro-8-hydroxynaphthalene-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-8-hydroxynaphthalene-1,4-dione(52431-59-1)
• EPA Substance Registry System: 5-chloro-8-hydroxynaphthalene-1,4-dione(52431-59-1)

Safety Data

• Hazardous Substances Data: 52431-59-1(Hazardous Substances Data)

Upstream product

• 68217-36-7 5-amino-8-hydroxy-[1,4]naphthoquinone 
• 108-31-6 maleic anhydride 
• 371-41-5 4-Fluorophenol 
• 605-71-0 1,5-dinitronaphthalene 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 89474-91-9 1-Benzyloxy-4-chlor-5,8-dimethoxynaphthalin 
• 89474-92-0 8-Benzyloxy-5-chlor-4-methoxy-1-naphthol 
• 89474-89-5 5-Benzyloxy-8-chlor-1,4-naphthochinon 

Relevant articles and documents

NEW NAPHTHO[2,3-B]FURAN DERIVATIVES

The present invention provides a compound useful as a novel antitumor agent targeting a CSC that is important in continuous proliferation of malignant tumor, metastasis and recurrence of cancer, and its resistance to an antitumor agent; a medicament comprising the compound as an active ingredient; a pharmaceutical composition; and an antitumor agent; as well as a method of treating cancer and/or a method of preventing cancer. The present invention provides compounds represented by formula (I) : or pharmaceutically acceptable salts thereof, wherein X is an oxygen atom or sulfur atom; R1 is a hydrogen atom, an alkyl group, or the like; R2 is a halogen atom or the like; R3 is a hydrogen atom, an alkyl group, or the like; m is 0, 1, 2, 3, or 4; and n is 1, 2, 3, or 4 (with the proviso that the sum of m and n is 1, 2, 3, or 4).

Synthesis and pharmacological studies of some (1,4)-Naphthoquinono[3,2-c]-1H-pyrazoles, 2-Substituted Amino-1,4-naphthoquinones, and related compounds

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Dimeric Naphthoquinones, IX. - Isodiospyrin and Elliptinone. - Synthesis of 6,6'-Dimeric Bijuglones by Phenol Oxidation

Oxidative coupling of the naphthol 37a gave the potential natural product 7,7'-dimethyl-6,6'-bijuglone (5) and, in lower yield, isodiospyrin (21).Regiospecific syntheses of 5, elliptinone (10), and 6,6'-bijuglone (45a) were achieved by phenol oxidation of suitable substituted p-chloronaphthols.