52431-78-4

Basic information

• Product Name: 1-(4-Hydroxyphenyl)-2H-tetrazole-5-thione
• Synonyms: 4-(5-MERCAPTO-1H-TETRAZOL-1-YL)PHENOL;1-(4-HYDROXYPHENYL)-1H-TETRAZOLE-5-THIO&;1-(4-Hydroxyphenyl)-[1H]-tetrazol-5-thiol;1,2-Dihydro-1-(p-hydroxyphenyl)-5H-tetrazol-5-thion;1-(4-hydroxyphenyl)-2,5-dihydro-1H-1,2,3,4-tetrazole-5-thione;1-(4-Hydroxyphenyl)-1H-tetrazole-5-thiol 4-(5-Mercapto-1H-tetrazol-1-yl)phenol;1-(4-Hydroxyphenyl)-5-mercapto-1H-tetrazole;1-(4-Hydroxyphenyl)-1H-tetrazole-5(4H)-thione
• CAS NO: 52431-78-4
• Molecular Formula: C₇H₆N₄OS
• Molecular Weight: 194.21
• EINECS: 257-909-2
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Tetrazoles
• Mol File: 52431-78-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 170 °C (dec.)(lit.)
• Boiling Point: 332.8 °C at 760 mmHg
• Flash Point: 155.1 °C
• Appearance: /
• Density: 1.63 g/cm³
• Vapor Pressure: 7.35E-05mmHg at 25°C
• Refractive Index: 1.801
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: methanol: soluble25mg/mL, clear (colorless to pink to purple)
• PKA: 9.05±0.15(Predicted)
• CAS DataBase Reference: 1-(4-Hydroxyphenyl)-2H-tetrazole-5-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Hydroxyphenyl)-2H-tetrazole-5-thione(52431-78-4)
• EPA Substance Registry System: 1-(4-Hydroxyphenyl)-2H-tetrazole-5-thione(52431-78-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• RIDADR: 1325
• WGK Germany: 2
• TSCA: Yes
• HazardClass: 4.1
• PackingGroup: III
• Hazardous Substances Data: 52431-78-4(Hazardous Substances Data)

Usage

Uses

1-(4-Hydroxyphenyl)-1H-tetrazole-5-thiol may be used in the synthesis of organotin(IV) complexes.

General Description

1-(4-Hydroxyphenyl)-1H-tetrazole-5-thiol is a heterocyclic thionate. Iodimetric determination of 1-(4-hydroxyphenyl)-1H-tetrazole-5-thiol in alkaline medium, via volumetric titration with potentiometric end-point detection is reported. Coordination chemistry of 1-(4-hydroxyphenyl)-1H-tetrazole-5-thiol as ligand, having deprotonated heterocyclic thioamide group, has been reported.

InChI:InChI=1/C7H6N4OS/c12-6-3-1-5(2-4-6)11-7(13)8-9-10-11/h1-4,12H,(H,8,10,13)

Upstream product

• 30714-45-5 ammonium p-hydroxydithiocarbanilate 
• 123-30-8 4-amino-phenol 
• 68372-10-1 4-(4-hydroxyphenyl)-3-thiosemicarbazide 
• 145614-60-4 (Z)-2-<1-(4-hydroxyphenyl)-5(1H)-tetrazolylthio>indan-1-one oxime 
• 145614-39-7 (E)-2-<1-(4-hydroxyphenyl)-5(1H)-tetrazolylthio>indan-1-one oxime 
• 145614-20-6 (E)-2-<1-(4-hydroxyphenyl)-5(1H)-tetrazolylthio>acetaldehyde oxime 
• 145639-85-6 (Z)-2-<1-(4-hydroxyphenyl)-5(1H)-tetrazolylthio>acetaldehyde oxime 
• 115786-71-5 1,3-bis<1-(4-hydroxyphenyl)-5(1H)-tetrazolylthio>propan-2-one oxime 
• 145614-61-5 (Z)-2-<1-(4-hydroxyphenyl)-5(1H)-tetrazolylthio>-α-tetralone oxime 
• 145614-35-3 2-<1-(4-hydroxyphenyl)-5(1H)-tetrazolylthio>cyclohexanone oxime 
• 145614-31-9 2-<1-(4-hydroxyphenyl)-5(1H)-tetrazolylthio>cyclopentanone oxime 
• 23567-67-1 4-[1,2,3,4]thiatriazol-5-ylamino-phenol 

Downstream Products

• 165404-63-7 4-{5-[6-(tert-Butyl-dimethyl-silanyloxymethyl)-[1,2]dithiin-3-ylmethylsulfanyl]-tetrazol-1-yl}-phenol 
• 669055-87-2 4-(5-isopropylsulfanyl-tetrazol-1-yl)-phenol 
• 86878-96-8 1-(4-hydroxy)phenyl-1H-tetrazole-5-thiol, sodium salt 
• 1252046-50-6 methyl 2-{2-[1-(4-hydroxyphenyl)-1H-tetrazol-5-ylthio]acetamido}benzoate 
• 214328-23-1 C₁₇H₁₃Cl₂N₅O₄S 
• 1170728-74-1 C₁₂H₁₇N₄O₄PS 
• 726181-10-8 Ph₃Sn(1-(4-hydroxyphenyl)-1H-tetrazole-5-thiol^(1-)) 
• 726181-15-3 Ph₂Sn[1-(4-hydroxyphenyl)-1H-tetrazole-5-thiol^(1-)]2 
• 726181-09-5 (n-Bu)3Sn(1-(4-hydroxyphenyl)-1H-tetrazole-5-thiol^(1-)) 
• 726181-08-4 Me₃Sn(1-(4-hydroxyphenyl)-1H-tetrazole-5-thiol^(1-)) 

Relevant articles and documents

1,2-dithiins having antifungal activity

Novel 1,2-dithiin compounds useful as antifungal or anti-infective agents, as well as methods for their use as such, are described. The 1,2-dithiin compounds are particularly effective in treating infections, especially those caused by Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Candida krusei, Candida parapsilosis, Candida tropicalis, Trichophyton rubrum, Epidermophyton species, Microsporum species, Sporothrix species, Blastomyces dermatitidis, Coccidiodes immiitis, Histoplasma capsulatum, Herpes virus, Influenza virus, Cytomegalovirus, human immunodeficiency virus, retrovirus, Adenovirus, Papillomavirus, Paravirus, Arenavirus, Bunyavirus, Coronavirus, Paramyxovirus, Picornavirus, Rhabdovirus, Togavirus, Hepadnavirus, Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Klebsiella pneumoniae, Staphylococcus epidermis, Zanthomonus maltrophilia, Acinetobacter, Enterobacter cloacae, Serratia marscens, Listeria, Monocytogenes, Enterococcus faecalis, Streptococcus pyogenes; Streptococcus pneumonia, Viridans streptococci, Haemophilus influenzae, Proteus mirabills, Proteus vulgaris and Bacterioides fragilis.

Preparation of some 1,2,3,4-tetrazoles

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