52435-06-0

Basic information

• Product Name: [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate
• Synonyms: [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate;(Des-Gly10，D-Ala6，proethylamide9)-LRH;LHRH-A;LRH-A;luteinizing hormone releasing hormone (D-Ala^) analog;[D-Ala6]des-Gly10-GnRH ethylamide;[D-Ala6]des-Gly10-gonadotropin releasing hormone ethylamide;5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-D-Ala-L-Leu-L-Arg-L-Pro-NHEt
• CAS NO: 52435-06-0
• Molecular Formula: C56H78N16O12
• Molecular Weight: 1167.31852
• Mol File: 52435-06-0.mol
• Article Data: 0

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.48g/cm³
• Refractive Index: 1.694
• PKA: 9.82±0.15(Predicted)
• CAS DataBase Reference: [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate(52435-06-0)
• EPA Substance Registry System: [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate(52435-06-0)

Safety Data

• Hazardous Substances Data: 52435-06-0(Hazardous Substances Data)

Usage

Description

[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate is a complex chemical compound derived from the luteinizing hormone-releasing hormone (LH-RH). It is specifically modified at the 10th and 6th amino acid positions, with the removal of glycine from the 10th position and substitution of d-alanine for the 6th position. This modification enhances the activity and potency of the LH-RH hormone, which plays a crucial role in controlling reproductive function. [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate is in a salt form, consisting of ethylamide acetate and water molecules as a hydrate.

Uses

Used in Pharmaceutical Industry:
[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate is used as a pharmaceutical agent for the treatment of reproductive disorders. [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate's enhanced activity and potency in the LH-RH hormone pathway make it a potential candidate for developing new therapies to address various reproductive health issues.
Used in Research and Development:
In the field of research and development, [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate is used as a research tool to study the mechanisms and pathways of the luteinizing hormone-releasing hormone (LH-RH). [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate can help scientists better understand the role of LH-RH in reproductive function and develop targeted therapies for related conditions.
Used in Clinical Settings:
[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate is used as a clinical agent for diagnosing and managing reproductive hormone imbalances. Its ability to modulate the LH-RH hormone pathway makes it a valuable tool for healthcare professionals in assessing and treating patients with reproductive health concerns.

InChI:InChI=1/C56H78N16O12/c1-5-60-54(83)45-13-9-21-72(45)55(84)39(12-8-20-61-56(57)58)66-50(79)40(22-30(2)3)67-47(76)31(4)64-49(78)41(23-32-14-16-35(74)17-15-32)68-53(82)44(28-73)71-51(80)42(24-33-26-62-37-11-7-6-10-36(33)37)69-52(81)43(25-34-27-59-29-63-34)70-48(77)38-18-19-46(75)65-38/h6-7,10-11,14-17,26-27,29-31,38-45,62,73-74H,5,8-9,12-13,18-25,28H2,1-4H3,(H,59,63)(H,60,83)(H,64,78)(H,65,75)(H,66,79)(H,67,76)(H,68,82)(H,69,81)(H,70,77)(H,71,80)(H4,57,58,61)/t31-,38+,39+,40+,41+,42+,43+,44+,45+/m1/s1