52437-07-7Relevant articles and documents
Efficient and chirally specific synthesis of phenanthro-indolizidine alkaloids by parham-type cycloacylation
Wang, Ziwen,Li, Zheng,Wang, Kailiang,Wang, Qingmin
, p. 292 - 299 (2010)
A concise, efficient and modular route involving Parhamtype cycloacylation as the key step has been used to synthesize six enantiopure phenanthro- indolizidine alkaloids 1a-c. The preparation of enantiomerically pure tylophora alkaloids and their seco analogues on a large-scale is now feasible. The alcohol intermediates 8a-c, which are difficult to prepare by other synthetic methodologies, have been synthesized by a metallation-cyclization-reduction sequence in excellent yields.
