5244-88-2

Upstream product

• 5407-98-7 1-cyclobutyl-1-phenyl-methanone 
• 123245-94-3 (cyclobutylmethyl)magnesium bromide 
• 925-90-6 ethylmagnesium bromide 
• 678150-52-2 (Z)-3-phenyl-1-propenyl N,n-diisopropylcarbamate 
• 5244-80-4 N,N-Dimethyl-α-phenyl-cyclobutyl-methylamin 
• 6668-40-2 cyclobutyl-phenyl ketone oxime 
• 5244-84-8 (+/-)-cyclobutyl(phenyl)methanamine 

Downstream Products

• 82833-97-4 (1-bromo-1-phenylmethylene)cyclobutane 

Relevant academic research and scientific papers

A Close-to-Aromatize Approach for the Late-Stage Functionalization through Ring Closing Metathesis

An efficient approach for the synthesis of monosubstituted aromatic compounds relying on a ring-closing metathesis followed by spontaneous 1,2-elimination is presented. The efficiency for late-stage functionalization is highlighted in various solvents (up to 920 TON). This approach is compatible with strained cycles and other multiple bonds in the substrate.

C-O hydrogenolysis catalyzed by Pd-PMHS nanoparticles in the company of chloroarenes

Catalytic Pd(OAc)2 and polymethylhydrosiloxane (PMHS), in conjunction with aqueous KF, and a catalytic amount of an aromatic chloride, effects the chemo-, regio-, and stereoselective deoxygenation of benzylic oxygenated substrates at room temperature in THF. Preliminary mechanistic experiments suggest the process to involve palladium-nanoparticle-catalyzed hydrosilylation followed by C-O reduction. The chloroarene additive appears to facilitate the hydrogenolysis process through the slow controlled release of HCl.

Stereoselective synthesis of metalated cyclobutyl derivatives

Treatment of Z-vinyl carbamates with dicyclopentadienyl(diethyl)zirconium [Et2ZrCp2] leads to cyclobutyl-zirconocene derivatives in good yields and as a unique diastereoisomer. The reaction proceeds through a carbometalative ring-exp

Zinc-promoted reactions. 8. The effect of ring strain in the reduction of 1,2-dibenzoylcycloalkanes

Ring cleavage was the main route in the Zn reduction of 1 in neat AcOH, while selective carbonyl reduction predominated in the presence of LiCl. The less strained 2 underwent only carbonyl reduction with Zn/AcOH. The Clemmensen reduction of both 1 and 2 resulted mainly in acyclic products. The unstrained 3 was fairly resistant towards reduction, and did not undergo ring cleavage.