52448-16-5

Basic information

• Product Name: 4-BROMO-L-TRYPTOPHAN
• Synonyms: 4-BROMO-L-TRYPTOPHAN;(S)-2-Amino-3-(4-bromo-1H-indol-3-yl)propanoic acid;L-Tryptophan, 4-bromo-;4-Bromo-L-tryptophan≥ 98% (HPLC, Chiral purity);L-2-Amino-3-(4-bromoindolyl)propionic acid;L-Trp(4-Br)-OH
• CAS NO: 52448-16-5
• Molecular Formula: C₁₁H₁₁BrN₂O₂
• Molecular Weight: 283.12
• Mol File: 52448-16-5.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-BROMO-L-TRYPTOPHAN(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-L-TRYPTOPHAN(52448-16-5)
• EPA Substance Registry System: 4-BROMO-L-TRYPTOPHAN(52448-16-5)

Safety Data

• Hazardous Substances Data: 52448-16-5(Hazardous Substances Data)

Usage

Description

4-BROMO-L-TRYPTOPHAN, also known as a fluorescent amino acid derivative, is a pale yellow solid with unique chemical properties. It is widely utilized in various applications due to its distinctive characteristics and potential benefits in different industries.

Uses

Used in Biological Spectroscopy and Microscopy:
4-BROMO-L-TRYPTOPHAN is used as a key component in the synthesis of fluorescent proteins, which are essential for biological spectroscopy and microscopy. The application reason is its ability to enhance the visualization and analysis of cellular processes and structures, contributing to a better understanding of biological systems.
Used in Pharmaceutical Research:
4-BROMO-L-TRYPTOPHAN is used as a research tool for the development of new drugs and therapies. The application reason is its potential to serve as a building block for novel pharmaceutical compounds, which can be tailored to target specific biological pathways or receptors.
Used in Chemical Synthesis:
4-BROMO-L-TRYPTOPHAN is used as an intermediate in the chemical synthesis of various compounds, including those with potential applications in the pharmaceutical, agrochemical, and materials science industries. The application reason is its unique chemical properties, which allow for the creation of a diverse range of products with specific functionalities.

Upstream product

• 98600-34-1 4-bromo-1H-indole-3-carbaldehyde 
• 691885-26-4 dl-4-bromo-N-(tert-butoxycarbonyl)tryptophan 
• 162893-62-1 (S)-4-bromo-N-(tert-butoxycarbonyl)-1-tosyltryptophan methyl ester 
• 52488-36-5 4-bromo-1H-indole 
• 56-45-1 L-serin 
• 691885-32-2 (S)-4-bromo-N-(tert-butoxycarbonyl)tryptophan methyl ester 
• 252026-08-7 N-acetyl-4-bromo-DL-tryptophan 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 33062-26-9 (-)-trans-clavicipitic acid 
• 73-22-3 L-Tryptophan 

Relevant articles and documents

Preparation method of non-natural L - tryptophan derivative

The invention discloses a preparation method of a non-natural L - tryptophan derivative, which is sequentially subjected to formylation by adopting a cheap and easily available substituted indole compound as a raw material. Cyclization, ring opening, asym

General synthesis of unnatural 4-, 5-, 6-, and 7-bromo-D-tryptophans by means of a regioselective indole alkylation

A general two-step approach to enantiopure bromotryptophans from unprotected bromoindoles has been developed. Indole nucleophiles prepared with MeMgCl in the presence of CuCl reacted with cyclic sulfamidates derived from enantiopure D-serine to form 4-, 5-, 6-, or 7-bromo-D-tryptophan and some other halogenated tryptophans in moderate yields but with complete regioselectivity. The bromotryptophan derivatives were deprotected using mild conditions.

ANTIBACTERIAL COMPOUNDS

Novel compounds having antimicrobial activitiy, in particular against Pseudomonas aeruginosa, Burkholderia cepaciaand/or Clostridium difficile, and a pharmaceutical composition containing the novel compound.