52449-32-8

Usage

Classification

α-bromomethyl aryl ketone

Uses

Building block in the production of various pharmaceuticals, agrochemicals, and other fine chemicals

Appearance

Colorless to pale yellow liquid

Odor

Sharp, sweet, fragrance

Solubility

Slightly soluble in water, highly soluble in organic solvents

Hazardous nature

Considered hazardous to human health and the environment

Upstream product

• 30314-44-4 2,2-dimethyl-1-(4-methylphenyl)-1-propanone 

Downstream Products

• 89727-74-2 <4-(2,2-dimethyl-1-oxopropyl)benzyl>triphenylphosphonium bromide 
• 85010-90-8 ethyl 2-chloro-3-(4-pivaloylphenyl)propionate 
• 328397-78-0 1-[4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxymethyl)-phenyl]-2,2-dimethyl-propan-1-one 
• 328397-80-4 2,2-dimethyl-1-[4-(2-phenyl-[1,3]dioxan-5-yloxymethyl)-phenyl]-propan-1-one 
• 328397-43-9 1-[4-(2,3-dihydroxy-propoxymethyl)-phenyl]-2,2-dimethyl-propan-1-one 
• 328397-82-6 1-[4-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]phenyl]-2,2-dimethyl-1-propanone 
• 85002-50-2 5-[4-(2,2-Dimethyl-propionyl)-benzyl]-thiazolidine-2,4-dione 
• 53780-45-3 bis-(p-pivaloylbenzyl)malonic acid diethyl ester 
• 63177-27-5 4'-(phthalimidomethyl)pivalophenone 
• 62713-07-9 4-{[methyl(p-pivaloylbenzyl)-amino]methyl}benzophenone hydrochloride 
• 62808-84-8 4'-[bis(4-pivaloylbenzyl)aminomethyl]-2,2-dimethyl-propiophenone hydrochloride 
• 62287-16-5 2-methyl-2-(p-pivaloyl phenyl)-propionic acid 
• 52449-33-9 p-pivaloyl phenyl acetonitrile 

Relevant academic research and scientific papers

Steric Effects on Rates of Dehalogenation of Anion Radicals Derived from Substituted Nitrobenzyl Halides

One-electron reduction of nitrobenzyl halides produces the anion radicals, which subseqently undergo dehalogenation to form nitrobenzyl radicals.The rate constants for these processes have been studied by pulse radiolysis in aqueous alcoholic solutions. α

Iminodimethylene di-tert-alkylophenones and phenols

Substituted-iminodimethylene-di-tert-alkylophenones, e.g., 4", 4"'-methyliminodimethylene-dipivalophenone, are prepared by treating a corresponding α-halo-p-tert-alkanoyl toluene with a substituted amine. The phenylcarbinols are prepared from the corresponding phenones and both the phenones and the phenylcarbinols are useful as hypolipidemic agents.

Thiodimethylene bis(pivalophenone)

Substituted or unsubstituted thiodimethylene bis(pivalophenone), e.g., 4',4'"-(thiodimethylene) bis(pivalophenone) are prepared by treating a corresponding α-halo-p-tert-alkanoyl toluene with an alkali metal sulfide and are useful as hypolipidemic agents.

Bis-substituted benzyl acetic acids

Bis-substituted benzyl acetic acids, e.g., bis-(p-pivaloylbenzyl)acetic acid, are prepared by hydrolyzing and decarboxylating a corresponding bis-(p-pivaloylbenzyl)malonic acid diethyl ester and are useful as hypolipidemic agents.

Acyl benzyl ethers

Acyl substituted or unsubstituted benzyl ethers, e.g., p-(phenoxymethyl)pivalophenone, are prepared by reacting a corresponding α-bromo-p-pivaloyl toluene with a corresponding phenol and are useful as hypolipidemic agents.

α-Bromo-pivaloyl toluenes

Acyl substituted phenyl alkanoic acids, e.g. p-pivaloyl phenyl acetic acid, are prepared by hydrolyzing p-pivaloyl phenyl acetonitriles and are useful as hypolipidemic agents.

Bromination process

The α-bromo-substituted or unsubstituted-4-pivaloyl toluenes, e.g., α-bromo-4-pivaloyl toluene, are prepared by bromination of a corresponding p-pivaloyl toluene with liquid bromine at a temperature of at least 100°C.