52450-36-9Relevant academic research and scientific papers
4-Alkyl- and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6- g]quinolines: Potent, nonsteroidal androgen receptor agonists
Higuchi, Robert I.,Edwards, James P.,Caferro, Thomas R.,Ringgenberg, Josef D.,Kong, James W.,Hamann, Lawrence G.,Arienti, Kristen L.,Marschke, Keith B.,Davis, Robert L.,Farmer, Luc J.,Jones, Todd K.
, p. 1335 - 1340 (2007/10/03)
A series of human androgen receptor (hAR) agonists based on 4-alkyl-; 4,4-dialkyl-; and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6-g]quinoline was synthesized and evaluated in competitive receptor binding assays and an androgen receptor cotransfection assay in a mammalian cell background. A number of compounds in this series demonstrated activity equal to or better than dihydrotestosterone in both assays and represent a novel class of compounds for use in androgen replacement therapy.
Photocyclisation of Enamides. Part 14. Substituent Effects in the Photocyclisation of N-α,β-Unsaturated Acylanilides.
Ninomiya, Ichiya,Kiguchi, Toshiko,Yamauchi, Sadami,Naito, Takeaki
, p. 197 - 202 (2007/10/02)
Irradiation of N-α,β-unsaturated acylanilides having various substituents on the benzene ring yielded a mixture of cis- and trans-octahydrophenanthridones (3a-f) and dihydroquinolones (5a, e, and f).The N-alkylanilides (
