52459-01-5Relevant academic research and scientific papers
SYNTHESIS OF DERIVATIVES STRUCTURALLY RELATED TO GLAZIOVINE
Bellamy, F. D.,Chazan, J. B.,Ou, K.
, p. 2803 - 2806 (2007/10/02)
Three compounds, 2a, 2b, and 2c have been synthesized by an analogy with glaziovine 1 which has been claimed to have anxiolytic properties similar to diazepam.The intermediates indanones 5 have been obtained according to conventional (for 5a) or less conventional procedure (5b) and then converted to the corresponding indanones 11.Michael addition of methylbenzylamine followed by a one-carbon homologation of the ketone gave an aldehyde suitable for Robinson annulation leading to the spiro compounds 2.DDQ oxidation gave 3.No anxiolytic activity was found from the pharmacological data.
