52474-37-0

Downstream Products

• 1504578-45-3 O,O'-di(3'-O-acetyl-α-D-thymidine-5'-yl) [4-(methoxycarbonyl)phenylaminocarbonyl]methylphosphonate 
• 1504578-46-4 O,O'-di(3'-O-acetyl-α-D-thymidine-5'-yl) [3,5-bis(trifluoromethyl)phenylaminocarbonyl]methylphosphonate 

Relevant academic research and scientific papers

OLIGONUCLEOTIDE AND NUCLEIC ACID SYNTHESIS

The present invention relates to methods for the high fidelity synthesis of oligonucleotides and polynucleotides on a solid surface. In particular, the invention relates to methods of synthesising oligonucleotides, polynucleotides, and doublestranded polynucleotides/nucleic acids, such as DNA and XNA, wherein the process comprises thermally controlled deprotection steps at the 5'-OH of previously coupled nucleosides or nucleotides at selected sites on the surface of the substrate.