52479-64-8

Basic information

• Product Name: 3-(2,6-Dichlorophenyl)propenoyl chloride
• Synonyms: 3-(2,6-Dichlorophenyl)propenoyl chloride
• CAS NO: 52479-64-8
• Molecular Formula: C₉H₅Cl₃O
• Molecular Weight: 235.4944
• Mol File: 52479-64-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 330.4°Cat760mmHg
• Flash Point: 139.3°C
• Appearance: /
• Density: 1.446g/cm³
• Vapor Pressure: 0.000166mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 3-(2,6-Dichlorophenyl)propenoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,6-Dichlorophenyl)propenoyl chloride(52479-64-8)
• EPA Substance Registry System: 3-(2,6-Dichlorophenyl)propenoyl chloride(52479-64-8)

Safety Data

• Hazardous Substances Data: 52479-64-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H5Cl3O/c10-7-2-1-3-8(11)6(7)4-5-9(12)13/h1-5H/b5-4+

Upstream product

• 20595-49-7 (2E)-3-(2,6-dichlorophenyl)prop-2-enoic acid 

Downstream Products

• 137872-84-5 4-Amino-6-(2',6'-dichloro-trans-cinnamoyl)amino-2-methyl-quinoline 
• 85995-36-4 (E)-3-(2,6-dichlorophenyl)acrylamide 
• 92021-54-0 trans-N,N-Diethyl-2,6-dichlor-zimtsaeure-amid 
• 1092480-04-0 N-{7-[(2E)-3-(2,6-dichlorophenyl)prop-2-enoyl]-2,3-dimethylimidazo[1,2-a]pyridin-8-yl}-2,2-dimethylpropanamide 
• 85995-41-1 N,N-dimethyl-2,6-dichloro-cis-cinnamide 
• 85995-39-7 N-methyl-2,6-dichloro-cis-cinnamide 
• 85995-36-4 2,6-dichloro-cis-cinnamide 
• 59507-32-3 phenyl 2,6-dichloro-trans-cinnamate 
• 59507-33-4 tert-butyl 2,6-dichloro-trans-cinnamate 
• 59507-31-2 isopropyl 2,6-dichloro-trans-cinnamate 
• 85995-38-6 N,N-dimethyl-2,6-dichloro-trans-cinnamide 
• 59507-30-1 ethyl (E)-3-(2,6-dichlorophenyl)prop-2-enoate 
• 59507-34-5 n-octyl 2,6-dichloro-trans-cinnamate 
• 85995-35-3 p-bromophenyl 2,6-dichloro-trans-cinnamate 

Relevant articles and documents

Antifungal Exploration of Quinoline Derivatives against Phytopathogenic Fungi Inspired by Quinine Alkaloids

Enlightened from our previous work of structural simplification of quinine and innovative application of natural products against phytopathogenic fungi, lead structure 2,8-bis(trifluoromethyl)-4-quinolinol (3) was selected to be a candidate and its diversified design, synthesis, and antifungal evaluation were carried out. All of the synthesized compounds Aa1-Db1 were evaluated for their antifungal activity against four agriculturally important fungi, Botrytis cinerea, Fusarium graminearum, Rhizoctonia solani, and Sclerotinia sclerotiorum. Results showed that compounds Ac3, Ac4, Ac7, Ac9, Ac12, Bb1, Bb10, Bb11, Bb13, Cb1. and Cb3 exhibited a good antifungal effect, especially Ac12 had the most potent activity with EC50 values of 0.52 and 0.50 μg/mL against S. sclerotiorum and B. cinerea, respectively, which were more potent than those of the lead compound 3 (1.72 and 1.89 μg/mL) and commercial fungicides azoxystrobin (both >30 μg/mL) and 8-hydroxyquinoline (2.12 and 5.28 μg/mL). Moreover, compound Ac12 displayed excellent in vivo antifungal activity, which was comparable in activity to the commercial fungicide boscalid. The preliminary mechanism revealed that compound Ac12 might cause an abnormal morphology of cell membranes, an increase in membrane permeability, and release of cellular contents. These results indicated that compound Ac12 displayed superior in vitro and in vivo fungicidal activities and could be a potential fungicidal candidate against plant fungal diseases.

BENZIMIDAZOLE OR INDOLE AMIDES AS INHIBITORS OF PIN1

The invention relates to compounds of the formula (1) and to pharmaceutically acceptable salts and solvates thereof, wherein the variables are defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders that contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).