524953-12-6

Basic information

• Product Name: (4-chloro-1-phenyl-4H-2,3,6,10b-tetraaza-benzo[e]azulen-5-yl)-dimethyl-amine
• Synonyms: (4-chloro-1-phenyl-4H-2,3,6,10b-tetraaza-benzo[e]azulen-5-yl)-dimethyl-amine
• CAS NO: 524953-12-6
• Molecular Weight: 337.812
• Mol File: 524953-12-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-chloro-1-phenyl-4H-2,3,6,10b-tetraaza-benzo[e]azulen-5-yl)-dimethyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chloro-1-phenyl-4H-2,3,6,10b-tetraaza-benzo[e]azulen-5-yl)-dimethyl-amine(524953-12-6)
• EPA Substance Registry System: (4-chloro-1-phenyl-4H-2,3,6,10b-tetraaza-benzo[e]azulen-5-yl)-dimethyl-amine(524953-12-6)

Safety Data

• Hazardous Substances Data: 524953-12-6(Hazardous Substances Data)

Upstream product

• 133118-22-6 N,N-dimethyl-1-phenyl-4H-<1,2,4>triazolo<4,3-a><1,5>benzodiazepin-5-amine 

Relevant articles and documents

1,5-Benzodiazepines: Part XIII. Substituted 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5-amines and 4H-imidazo[1,2-a][1,5]benzodiazepin-5-amines as analgesic, anti-inflammatory and/or antipyretic agents with low acute toxicity

The reaction of proper N,N-dialkyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5-amines (1) with N-chlorosuccinimide afforded their 4-chloroderivatives 3 which in turn were treated with cyclic amines to give the corresponding 4,5-diaminoderivatives 4. The N,N-dialkyl-4H-imidazo[1,2-a][1,5]benzodiazepin-5-amines (5) were prepared starting from suitable 4-(dialkylamino)-1,3-dihydro-2H-1,5-benzodiazepin-2-ones (8), through multistep synthetic routes. At the 200 mg kg-1 os dose, some compounds 3 and 4 showed notable analgesic or anti-inflammatory activity but no antipyretic properties, whereas the 5-(dibutylamino) derivatives 5b and 5f proved to be significantly endowed with all these activities. Almost all the compounds 3, 4 and 5 did not show acute toxicity in mice up to 800 mg kg-1 os dose.