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Usage

Uses

Used in Polymer Chemistry:
(2E)-4-(4-dodecylphenyl)-4-oxobut-2-enoic acid is used as a photoinitiator for photopolymerization reactions, where it plays a crucial role in absorbing light and initiating the crosslinking of monomers to form polymers. This application is particularly important in the production of materials with specific properties tailored for various uses.
Used in Plastics and Coatings Industry:
In the plastics and coatings industry, (2E)-4-(4-dodecylphenyl)-4-oxobut-2-enoic acid serves as a UV absorber and stabilizer. Its ability to enhance the resistance of plastics and coatings to degradation from UV light is vital for improving the longevity and performance of these materials, especially those exposed to sunlight or other UV sources.
Used in Organic Electronic Devices:
(2E)-4-(4-dodecylphenyl)-4-oxobut-2-enoic acid has potential applications in the development of organic electronic devices. Its unique properties may contribute to the creation of more efficient and versatile devices in this rapidly growing field.
Used in Organic Synthesis:
As a building block for the synthesis of other organic compounds, (2E)-4-(4-dodecylphenyl)-4-oxobut-2-enoic acid is a valuable component in organic chemistry. Its versatility allows it to be incorporated into a wide range of chemical reactions, leading to the production of new and useful compounds.

Upstream product

• 108-31-6 maleic anhydride 
• 123-01-3 1-dodecylbenzene 

Downstream Products

• 21021-55-6 4-dodecylbenzoic acid 

Relevant academic research and scientific papers

Antiproliferative activity of aroylacrylic acids. Structure-activity study based on molecular interaction fields

Antiproliferative activity of 27 phenyl-substituted 4-aryl-4-oxo-2-butenoic acids (aroylacrylic acids) toward Human cervix carcinoma (HeLa), Human chronic myelogenous leukemia (K562) and Human colon tumor (LS174) cell lines in vitro are reported. Compounds are active toward all examined cell lines. The most active compounds bear two or three branched alkyl or cycloalkyl substituents on phenyl moiety having potencies in low micromolar ranges. One of most potent derivatives arrests the cell cycle at S phase in HeLa cells. The 3D QSAR study, using molecular interaction fields (MIF) and derived alignment independent descriptors (GRIND-2), rationalize the structural characteristics correlated with potency of compounds. Covalent chemistry, most possibly involved in the mode of action of reported compounds, was quantitatively accounted using frontier molecular orbitals. Pharmacophoric pattern of most potent compounds are used as a template for virtual screening, to find similar ones in database of compounds screened against DTP-NCI 60 tumor cell lines. Potency of obtained hits is well predicted.

2-[(Carboxymethyl)sulfanyl]-4-oxo-4-arylbutanoic acids selectively suppressed proliferation of neoplastic human HeLa cells. A SAR/QSAR study

A series of twenty alkyl-, halo-, and methoxy-aryl-substituted 2-[(carboxymethyl)sulfanyl]-4-oxo-4-arylbutanoic acids were synthesized. The new compounds, called CSAB, suppressed proliferation of human cervix carcinoma, HeLa cells, in vitro in a concentration range of 0.644 to 29.48 μM/L. Two compounds exhibit antiproliferative activity in sub-micromolar concentrations (16, 19). Five compounds act in low micromolar concentrations ( 10). A strong structure-activity relationship, using estimated log P values and BCUT descriptors, was observed.