52500-61-5

Basic information

• Product Name: Beta-Amino-Alpha-methyl-benzeneethanol
• Synonyms: Beta-Amino-Alpha-methyl-benzeneethanol;b-Amino-a-methylphenethyl Alcohol;1-Amino-1-phenyl-2-propanol;1-Phenyl-2-hydroxypropylamine;Benzeneethanol, b-aMino-a-Methyl-
• CAS NO: 52500-61-5
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.20562
• Mol File: 52500-61-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 76-80℃
• Boiling Point: 288℃
• Flash Point: 128℃
• Appearance: /
• Density: 1.071
• Vapor Pressure: 0.0011mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: Beta-Amino-Alpha-methyl-benzeneethanol(CAS DataBase Reference)
• NIST Chemistry Reference: Beta-Amino-Alpha-methyl-benzeneethanol(52500-61-5)
• EPA Substance Registry System: Beta-Amino-Alpha-methyl-benzeneethanol(52500-61-5)

Safety Data

• Hazardous Substances Data: 52500-61-5(Hazardous Substances Data)

Usage

General Description

Beta-Amino-Alpha-methyl-benzeneethanol is a chemical compound that belongs to the class of aromatic alcohols. It is also known as Phendimetrazine, which functions as a stimulant and appetite suppressant, making it useful in the treatment of obesity. The chemical structure of Beta-Amino-Alpha-methyl-benzeneethanol includes a beta-amino group, an alpha-methyl group, and a benzene ring, giving it its pharmacological properties. It is commonly used in weight loss medications and has a potential for abuse and dependence due to its stimulating effects on the central nervous system. It is important to use this chemical under proper medical guidance and supervision to avoid potential side effects and health risks.

InChI:InChI=1/C9H13NO/c1-7(11)9(10)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3

Upstream product

• 25355-34-4 1-phenyl-propane-1,2-dione 1-oxime 
• 491-82-7 isoephedrine 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 127209-38-5 1-Dimethylsilanyl-2,2,3-trimethyl-4-phenyl-[1,2]azasiletidine 
• 622-42-4 1-nitro-1-phenylmethane 
• 75-07-0 acetaldehyde 
• 4436-22-0 2-methyl-3-phenyloxirane 
• 91791-27-4 (+/-)-(Z)-2-hydroxy-1-phenyl-1-propanone oxime 
• 91791-26-3 (+/-)-(E)-2-hydroxy-1-phenyl-1-propanone oxime 
• 90917-82-1 5-methyl-4-phenyl-4,5-dihydro-oxazol-2-ylamine 
• 122898-35-5 C₁₆H₁₇NO₃ 
• 88784-94-5 4-nitro-benzoic acid-((1RS,2SR)-2-hydroxy-1-phenyl-propylamide) 
• 19901-87-2 threo-amino-1-phenyl-1-propanol-2 

Downstream Products

• 88784-94-5 4-nitro-benzoic acid-((1RS,2SR)-2-hydroxy-1-phenyl-propylamide) 
• 88122-90-1 (+/-)-5c-methyl-2,4r-diphenyl-4,5-dihydro-oxazole 
• 160745-23-3 N-methylisoephedrine 
• 174635-64-4 N-[α-(1-hydroxyethyl)benzyl]-2-phenylquinoline-4-carboxamide 
• 19901-87-2 (1R,2S/1R,2R)-1-amino-1-phenylpropan-2-ol 
• 88784-94-5 4-nitro-benzoic acid-((1RS,2RS)-2-hydroxy-1-phenyl-propylamide) 
• 174636-55-6 (R,S)-N-[α-(1-hydroxyethyl)benzyl]-3-methyl-2-phenylquinoline-4-carboxamide 
• 1200404-09-6 2-chloro-N-(4-(((2-hydroxy-1-phenylpropyl)amino)carbonyl)phenyl)benzamide 
• 1200404-12-1 2-chloro-N-(4-(5-methyl-4-phenyloxazol-2-yl)phenyl)benzamide 
• 1200404-10-9 2-chloro-N-(4-(((2-oxo-1-phenylpropyl)amino)carbonyl)phenyl)benzamide 
• 90917-82-1 5-methyl-4-phenyl-4,5-dihydro-oxazol-2-ylamine 
• 127744-61-0 (1S,2R)-1-Phenyl-2-{[1-thiophen-2-yl-meth-(E)-ylidene]-amino}-propan-1-ol 

Relevant articles and documents

Regio- and stereoselective multi-enzymatic aminohydroxylation of β-methylstyrene using dioxygen, ammonia and formate

We report an enzymatic route for the formal regio- and stereoselective aminohydroxylation of β-methylstyrene that consumes only dioxygen, ammonia and formate; carbonate is the by-product. The biocascade entails highly selective epoxidation, hydrolysis and hydrogen-borrowing alcohol amination. Thus, β-methylstyrene was converted into 1R,2R and 1S,2R-phenylpropanolamine in 59-63% isolated yields, and up to >99.5 : 0.5 dr and er.

Enantioselective synthesis of cyclic sulfamidates by using chiral rhodium-catalyzed asymmetric transfer hydrogenation

Asymmetric transfer hydrogenation (ATH) of cyclic sulfamidate imines 4 and 9, using a HCO2H/Et3N mixture as the hydrogen source and well-defined chiral Rh catalysts (S,S)- or (R,R)-2, CpRhCl(TsDPEN), effectively produces the corresponding cyclic sulfamidates with excellent yields and enantioselectivities at room temperature within 0.5 h. ATH of 4,5-disubstituted imines 9, having preexisting stereogenic centers, is shown to take place with dynamic kinetic resolution.

PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSYNE KINASES

Compounds of formula (I): and their use in the inhibition of Trk activity are described.