52509-14-5

Basic information

• Product Name: (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide
• Synonyms: LABOTEST-BB LT00233112;(1,3-DIOXOLAN-2-YLMETHYL)TRIPHENYLPHOSPHONIUM BROMIDE;(1,3-DIOXOLANE-2-YL METHYL) TRIPHENYL PHOSPHONIUM BROMIDE;TRIPHENYL-1,3-DIOXOLAN-2-YLMETHYL-PHOSPHONIUM BROMIDE;2-(1,3)-DIOXOLANE-2-YL-METHYLTRIPHENYLPHOSPHONIUM BROMIDE;Phosphonium, (1,3-dioxolan-2-ylmethyl)triphenyl-, bromide;(1,3-DIOXOLAN-2-YLMETHYL)TRIPHENYLPHOSPHONIUM BROMIDE 98%;(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide, 98 %
• CAS NO: 52509-14-5
• Molecular Formula: Br*C₂₂H₂₂O₂P
• Molecular Weight: 429.29
• EINECS: 257-977-3
• Product Categories: Dioxanes & Dioxolanes;Dioxolanes;Phosphonium Compounds;Synthetic Organic Chemistry;Wittig & Horner-Emmons Reaction;Wittig Reaction;C-C Bond Formation;Olefination;Wittig Reagents
• Mol File: 52509-14-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 193-195 °C(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: White to light brown/Powder or Crystals
• Density: g/cm³
• Storage Temp.: Store below +30°C.
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility: Soluble in water (20°C).
• Sensitive: Hygroscopic
• CAS DataBase Reference: (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide(52509-14-5)
• EPA Substance Registry System: (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide(52509-14-5)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 52509-14-5(Hazardous Substances Data)

Usage

Chemical Properties

white to light brown granular powder

Uses

Different sources of media describe the Uses of 52509-14-5 differently. You can refer to the following data:
1. (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium Bromide is used as a reactant in the synthesis of ketolides methyloxoerythromycins with antibacterial activity as highly potent against macrolide-resistant and susceptible respiratory pathogens.
2. Reactant for:Preparation of a ratiometric fluorescent probe for specific detection of cysteine over homocysteine and glutathioneMicrowave-assisted synthesis of KN-93 as inhibitor of calmodulin kinase IIPreparation of fluorinated spirobenzofuran piperidines as s1 receptor ligandsSynthesis and antitumor agentsRegio-selective preparation of indole derivatives via rhodium-catalyzed domino hydroformylation/indolization

Purification Methods

Wash the crystals with Et2O, dry them in a vacuum and recrystallise them from CH2Cl2/dry Et2O to give prisms m 172-174o, which is raised to 191.5-193o on drying at 56o/0.5mm. [Cresp et al. J Chem Soc, Perkin Trans 1 37 1974.]

InChI:InChI=1/C22H22O2P.BrH/c1-4-10-19(11-5-1)25(18-22-23-16-17-24-22,20-12-6-2-7-13-20)21-14-8-3-9-15-21;/h1-15,22H,16-18H2;1H/q+1;/p-1

Synthetic route

2-bromomethyl-1,3-dioxolane (4360-63-8) + triphenylphosphine (603-35-0) → (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5)

Conditions	Yield
In isopropyl alcohol at 60 - 65℃; for 3h; Inert atmosphere; Green chemistry;	99.1%
In toluene for 24h; Heating / reflux;	54%
at 120℃; for 24h;

2-bromomethyl-1,3-dioxolane (4360-63-8) → (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5)

Conditions	Yield
In toluene for 48h; Reflux;	33%

4,15-diformyl[2.2]paracyclophane (288156-11-6) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → 4,15-bis[(E)-2-formylvinyl]-[2.2]paracyclophane

Conditions	Yield
Stage #1: 4,15-diformyl[2.2]paracyclophane; (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 3h; Stage #2: With hydrogenchloride In tetrahydrofuran at 2℃; for 16h;	100%

(1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) + 4,15-bis[(1E,3E)-4-formylbuta-1,3-dienyl][2.2]paracyclophane → (2E,4E,6E)-7-[12-((1E,3E,5E)-7-Oxo-hepta-1,3,5-trienyl)-tricyclo[8.2.2.24,7]hexadeca-1(13),4(16),5,7(15),10(14),11-hexaen-5-yl]-hepta-2,4,6-trienal

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide; 4,15-bis[(1E,3E)-4-formylbuta-1,3-dienyl][2.2]paracyclophane With potassium tert-butylate In tetrahydrofuran at 20℃; for 3h; Stage #2: With hydrogenchloride In tetrahydrofuran at 2℃; for 16h;	100%

(1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) + p-(iodophenyl)carboxaldehyde (15164-44-0) → (E)-3-(4-iodophenyl)acrylaldehyde

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide; p-(iodophenyl)carboxaldehyde With 18-crown-6 ether; sodium hydride In tetrahydrofuran at 25℃; for 14h; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 25℃; for 6h;	100%
With 18-crown-6 ether; sodium hydride In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;	78.7%

mesytaldehyde (487-68-3) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → 2-(2,4,6-trimethylstyryl)-1,3-dioxolane

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 1h; Inert atmosphere; Stage #2: mesytaldehyde In tetrahydrofuran; mineral oil at 20℃; Inert atmosphere;	100%

(1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) + 5-((allyloxy)methyl)furan-2-carbaldehyde (113675-57-3) → C11H12O3

Conditions	Yield
With sodium methylate In methanol; N,N-dimethyl-formamide at 70℃; for 48h; Wittig Olefination; Inert atmosphere;	99%

(E)-3-(methylthio)cinnamaldehyde (1421970-17-3) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → (2E,4E)-5-(3-(methylthio)phenyl)penta-2,4-dienal (1421970-16-2)

Conditions	Yield
Stage #1: (E)-3-(methylthio)cinnamaldehyde; (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With sodium methylate In methanol at 25℃; Wittig Olefination; Inert atmosphere; Stage #2: With iodine In methanol; acetone for 12h; Inert atmosphere; Reflux;	96.2%

C17H26O (860032-97-9) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → C19H28O (1254522-05-8)

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: C17H26O In tetrahydrofuran at 20℃; Wittig reaction; Inert atmosphere; Stage #3: With oxalic acid In tetrahydrofuran; water	96%

quinoline-4-carboxaldehyde (4363-93-3) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → 4-((E)-2-[1,3]Dioxolan-2-yl-vinyl)-quinoline (172678-77-2)

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at -35 - 10℃; for 4h;	95%
With lithium methanolate In methanol; N,N-dimethyl-formamide at 70 - 80℃; for 4h;
With potassium tert-butylate In tetrahydrofuran

(1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) + 1-benzyl, 2-methyl (2RS,5RS,6RS)-5-ethyl-6-(2-oxoethyl)piperidine-1,2-dicarboxylate → 1-benzyl, 2-methyl (2RS,5RS,6RS)-6-[3-(1,3-dioxolan-2-yl)prop-2-enyl]-5-ethylpiperidine-1,2-dicarboxylate

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran Condensation; Wittig reaction;	95%
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran for 0.5h; Stage #2: 1-benzyl, 2-methyl (2RS,5RS,6RS)-5-ethyl-6-(2-oxoethyl)piperidine-1,2-dicarboxylate In tetrahydrofuran Wittig reaction; Further stages.;	95%

C21H30O (1254522-33-2) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → C23H32O (1254522-09-2)

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: C21H30O In tetrahydrofuran at 20℃; Wittig reaction; Inert atmosphere; Stage #3: With oxalic acid In tetrahydrofuran; water	95%

(1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) + 7-diethylaminocoumarine-3-aldehyde (57597-64-5) → (E)-3-(7-(diethylamino)-2-oxo-2H-chromen-3-yl)acrylaldehyde (1403769-30-1)

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide; 7-diethylaminocoumarine-3-aldehyde In dichloromethane at 20℃; for 0.5h; Stage #2: With sodium hydroxide In dichloromethane at 20℃; for 3h; Stage #3: With hydrogenchloride In dichloromethane at 20℃; for 0.2h;	95%

(1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) + 5-(N,N-dibutylamino)-thiophene-2-carbaldehyde (159874-90-5) → (E)-3-(5-(dibutylamino)thiophene-2-yl)acrylaldehyde

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran for 0.5h; Wittig Olefination; Cooling with ice; Stage #2: 5-(N,N-dibutylamino)-thiophene-2-carbaldehyde In tetrahydrofuran at 20℃; Stage #3: With oxalic acid In tetrahydrofuran; water for 24h;	94%

C19H28O (1254522-05-8) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → C21H30O (1254522-33-2)

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: C19H28O In tetrahydrofuran at 20℃; Wittig reaction; Inert atmosphere; Stage #3: With oxalic acid In tetrahydrofuran; water	93%

(E)-3-(5-(dimethylamino)thiophen-2-yl)acrylaldehyde + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → (2E,4E)-5-(5-(dimethylamino)thiophen-2-yl)penta-2,4-dienal

Conditions	Yield
With 18-crown-6 ether; sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 12h;	92.9%

3-(4-dimethylamino-phenyl)-propenal (20432-35-3, 6203-18-5) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → s-trans-((2trans-4trans)-5-(4-dimethylaminophenyl)phenyl)penta-2,4-dienal (20432-36-4)

Conditions	Yield
Stage #1: 3-(4-dimethylamino-phenyl)-propenal; (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With 18-crown-6 ether; sodium hydride In tetrahydrofuran at 20℃; Wittig reaction; Stage #2: With hydrogenchloride In tetrahydrofuran at 20℃; for 2h;	92%
With 18-crown-6 ether; sodium hydride In tetrahydrofuran at 20℃; for 12h;	58.6%
Stage #1: 3-(4-dimethylamino-phenyl)-propenal; (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With 18-crown-6 ether; sodium hydride In tetrahydrofuran at 20℃; for 2h; Wittig Rearrangement; Cooling with ice; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 20℃; for 0.5h; Stage #3: With potassium carbonate In tetrahydrofuran; water at 20℃;	55%
Stage #1: 3-(4-dimethylamino-phenyl)-propenal; (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With 18-crown-6 ether; sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 12h; Wittig Olefination; Stage #2: With hydrogenchloride at 20℃; for 0.5h;	39%
Stage #1: 3-(4-dimethylamino-phenyl)-propenal; (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With 18-crown-6 ether; sodium hydride In tetrahydrofuran Stage #2: With hydrogenchloride In tetrahydrofuran

(1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) + 4,15-bis[(E)-2-formylvinyl]-[2.2]paracyclophane → 4,15-bis[(1E,3E)-4-formylbuta-1,3-dienyl][2.2]paracyclophane

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide; 4,15-bis[(E)-2-formylvinyl]-[2.2]paracyclophane With potassium tert-butylate In tetrahydrofuran at 20℃; for 3h; Stage #2: With hydrogenchloride In tetrahydrofuran at 2℃; for 16h;	92%

(1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) + (2-[(N-benzylprolyl)amino]benzophenone) (95019-19-5) → (2E,8E,10E)-dodeca-2,8,10-trienal (864818-23-5)

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate at 0℃; Stage #2: (2-[(N-benzylprolyl)amino]benzophenone) for 1h; Stage #3: With oxalic acid at 20℃; Further stages.;	91%
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.5h; Stage #2: (2-[(N-benzylprolyl)amino]benzophenone) In tetrahydrofuran at 0℃; for 3h;	64%

(1S,2R)-1-(3,4-dichlorophenyl)-2-formyl-cyclopropanecarboxylic acid (4-fluorobenzyl)methylamide (846060-69-3) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → sodium cyanoborohydride (25895-60-7)

Conditions	Yield
With potassium hexamethylsilazane In tetrahydrofuran at 20℃; for 2h;	91%

C15H24O (1242261-02-4) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → C17H26O (860032-97-9)

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: C15H24O In tetrahydrofuran at 20℃; Wittig reaction; Inert atmosphere; Stage #3: With oxalic acid In tetrahydrofuran; water	91%

2-methylthiobenzaldehyde + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → (E)-2-methylthiocinnamaldehyde (1356939-86-0)

Conditions	Yield
Stage #1: 2-methylthiobenzaldehyde; (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With sodium hydride; 18-crown-6 ether In tetrahydrofuran at 20℃; Stage #2: With hydrogenchloride; water In tetrahydrofuran at 0℃;	90.4%

6-Methyl-hept-5-en-2-on (110-93-0) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → (E/Z)-3,7-dimethyl-2,6-octadienal (5392-40-5)

Conditions	Yield
With potassium hydroxide In isopropyl alcohol at 10 - 20℃; for 4h; Inert atmosphere; Green chemistry;	90.1%

(1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) + 1-benzyl, 2-methyl (2RS,5RS,6RS)-5-[(tert-butyldimethylsilyl)oxy]-6-(2-oxoethyl)piperidine-1,2-dicarboxylate → 1-benzyl, 2-methyl (2RS,5RS,6RS)-5-[(tert-butyldimethylsilyl)oxy]-6-[3-(1,3-dioxolan-2-yl)prop-2-enyl]piperidine-1,2-dicarboxylate

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran for 0.5h; Stage #2: 1-benzyl, 2-methyl (2RS,5RS,6RS)-5-[(tert-butyldimethylsilyl)oxy]-6-(2-oxoethyl)piperidine-1,2-dicarboxylate In tetrahydrofuran Wittig reaction; Further stages.;	90%

(1RS,2RS,3RS,4RS,6SR)-6-hydroxy-3,4,6-trimethyl-5,8-dioxobicyclo[2.2.2]octane-2-carbaldehyde + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → (1RS,3SR,4RS,7RS,8SR)-8-[2-(1,3-dioxolan-2-yl)-vinyl]-3-hydroxy-1,3,7-trimethylbicyclo[2.2.2]octane-2,6-dione

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.5h; Stage #2: (1RS,2RS,3RS,4RS,6SR)-6-hydroxy-3,4,6-trimethyl-5,8-dioxobicyclo[2.2.2]octane-2-carbaldehyde In tetrahydrofuran at 20℃; for 0.333333h; Wittig reaction; Further stages.;	90%

C23H32O (1254522-09-2) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → C25H34O (1254522-11-6)

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: C23H32O In tetrahydrofuran at 20℃; Wittig reaction; Inert atmosphere; Stage #3: With oxalic acid In tetrahydrofuran; water	90%

trans-4-(4-pentylcyclohexyl)-cyclohexane carboxaldehyde + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → C22H38O2

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at -30℃; for 1h; Stage #2: trans-4-(4-pentylcyclohexyl)-cyclohexane carboxaldehyde In tetrahydrofuran at 20℃; for 5h;	90%

(1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) + 6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-carbaldehyde (564-94-3) → (E)-3-(6,6-dimethyl-bicyclo[3.1.1]hept-2-en-2-yl)prop-2-enal (124931-24-4)

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.5h; Sealed tube; Inert atmosphere; Stage #2: 6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-carbaldehyde In tetrahydrofuran at 20℃; for 6h; Sealed tube; Inert atmosphere;	90%

pyridine-4-carbaldehyde (872-85-5) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → (E)-3-(pyridin-4-yl)acrylaldehyde (32986-66-6)

Conditions	Yield
Stage #1: pyridine-4-carbaldehyde; (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With 18-crown-6 ether; sodium hydride In tetrahydrofuran at 20℃; Wittig reaction; Stage #2: With hydrogenchloride In tetrahydrofuran at 20℃; for 2h;	89%

(1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) + 4-(1H-pyrazol-1-yl)benzaldehyde (99662-34-7) → (2E)-3-[4-(1H-Pyrazol-1-yl)phenyl]-2-propenal (545424-10-0)

Conditions	Yield
Stage #1: (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide; 4-(1H-pyrazol-1-yl)benzaldehyde With potassium carbonate; Tris(3,6-dioxaheptyl)amine In dichloromethane; water for 20h; Heating / reflux; Stage #2: With water; hydrogenchloride In tetrahydrofuran at 20℃; for 1h; Stage #3: With sodium hydroxide In tetrahydrofuran; water at 0℃;	89%

3-formyl-10-methylphenothiazine (4997-36-8) + (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide (52509-14-5) → (E)-3-(10-methyl-10H-phenothiazin-3-yl)acrylaldehyde (1374005-27-2)

Conditions	Yield
With Tris(3,6-dioxaheptyl)amine; potassium carbonate In dichloromethane for 20h; Reflux;	88.6%
Stage #1: 3-formyl-10-methylphenothiazine; (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With Tris(3,6-dioxaheptyl)amine; potassium carbonate In dichloromethane for 0.2h; Reflux; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 0 - 20℃; for 1h;	80%
Stage #1: 3-formyl-10-methylphenothiazine; (1,3-dioxolan-2-yl-methyl)triphenylphosphonium bromide With Tris(3,6-dioxaheptyl)amine; potassium carbonate In dichloromethane for 24h; Reflux; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 20℃; for 2h;	65%

Upstream product

• 4360-63-8 2-bromomethyl-1,3-dioxolane 
• 603-35-0 triphenylphosphine 

Downstream Products

• 65401-83-4 (E)-2-methoxy-4-(3-oxoprop-1-en-1-yl)phenyl acetate 
• 77972-48-6 styrene-α,4-dicarbaldehyde 
• 61650-52-0 (E)-2-(3-oxoprop-1-enyl)benzaldehyde 
• 791-28-6 Triphenylphosphine oxide 
• 592510-50-4 2-[(E)-2-(4-chlorophenyl)ethenyl]-1,3-dioxolane 

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