52516-37-7

Basic information

• Product Name: 2-(3,5-dichlorophenyl)acetonitrile
• Synonyms: 2-(3,5-dichlorophenyl)acetonitrile;3,5-Dichlorobenzyl cyanide;3,5-Dichlorophenylacetonitrile;Benzeneacetonitrile, 3,5-dichloro-;3,5-dichlorobenzeneacetonitrile
• CAS NO: 52516-37-7
• Molecular Formula: C₈H₅Cl₂N
• Molecular Weight: 186.04
• Mol File: 52516-37-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 287℃
• Flash Point: 124℃
• Appearance: /
• Density: 1.333
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(3,5-dichlorophenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-dichlorophenyl)acetonitrile(52516-37-7)
• EPA Substance Registry System: 2-(3,5-dichlorophenyl)acetonitrile(52516-37-7)

Safety Data

• Hazardous Substances Data: 52516-37-7(Hazardous Substances Data)

Usage

Uses

2-(3,5-Dichlorophenyl)acetonitrile is used in the synthesis of 6-arylpyrido[2,3-d]pyrimidines as ATP-competitive inhibitors of bacterial -alanine:-alanine ligase.

InChI:InChI=1/C8H5Cl2N/c9-7-3-6(1-2-11)4-8(10)5-7/h3-5H,1H2

Upstream product

• 151-50-8 potassium cyanide 
• 7778-01-0 3,5-dichlorobenzyl bromide 
• 143-33-9 sodium cyanide 
• 3290-06-0 1,3-dichloro-5-chloromethyl-benzene 
• 60211-57-6 3,5-dichlorobenzyl alcohol 
• 25186-47-4 3,5-dichlorotoluene 
• 6011-14-9 2-aminoacetonitrile hydrochloride 
• 67492-50-6 (3,5-dichlorophenyl)boronic acid 

Downstream Products

• 278600-55-8 8-(3,5-dichloro-phenyl)-2-methylsulfanyl-pyrazolo[1,5-a][1,3,5]triazin-4-ol 
• 51719-65-4 2-(3,5-dichlorophenyl)acetic acid 

Relevant articles and documents

Synthesis of α-aryl esters and nitriles: Deaminative coupling of α-aminoesters and α-aminoacetonitriles with arylboronic acids

Transition-metal-free synthesis of α-aryl esters and nitriles using arylboronic acids with α-aminoesters and α-aminoacetonitriles, respectively, as the starting materials has been developed. The reaction represents a rare case of converting C(sp3)-N bonds into C(sp3)-C(sp2) bonds. The reaction conditions are mild, demonstrate good functional-group tolerance, and can be scaled up. Touch base: A transition-metal-free protocol for the synthesis of α-aryl esters and nitriles by deaminative coupling is presented. Strong bases and transition-metal catalysts are not needed. The new synthetic method uses readily available starting materials and demonstrates wide substrate scope.

N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS

Disclosed are compounds which inhibit beta -amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta -amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

1,2,4-SUBSTITUERTE 1,2,3,4-TETRAHYDRO-AND 1,2 DIHYDRO-QUINOLINE AND 1,2,3,4-TETRAHYDRO-QUINOXALINE DERIVATIVES AS CETP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROSIS AND OBESITY

Quinoline and quinoxaline compounds of formula I and III wherein the subtituent are as defined in claims 1 and 15, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.