5252-98-2Relevant academic research and scientific papers
Preparation method for o-tolylacetic acid aryl formic acid derivative
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Paragraph 0092-0095, (2019/07/16)
The invention discloses a preparation method for an o-tolylacetic acid aryl formic acid derivative. According to the method, new C-C bonds can be formed, the organic o-tolylacetic acid aryl formic acid derivative is obtained, the good functional group tolerance is achieved, and the o-tolylacetic acid aryl formic acid derivative which cannot be easily obtained by adopting other methods can be synthesized; according to the method, adopted raw materials are easy to obtain, the yield is high, the reaction conditions are mild, the substrate range is wide, and after-treatment is simple and green.
Palladium-Catalyzed ortho-C-H Methylation of Benzoic Acids
Lv, Weiwei,Wen, Si,Liu, Jing,Cheng, Guolin
, p. 9786 - 9791 (2019/08/26)
A palladium-catalyzed methylation of C-H bonds of benzoic acids with di-tert-butyl peroxide as the methylating reagent under an external oxidant and ligand-free conditions has been achieved. The reaction is found to be directed by a weakly coordinating carboxyl group, offering a facile route for the synthesis of highly functionalized ortho-methyl benzoic acids.
Process for preparing 4, 5-dichloro-2-methylbenzoic acid
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, (2008/06/13)
The present invention relates to a process for preparing 4,5-dichloro-2-methylbenzoic acid and also its salts in high yields and in high purities by reacting 3,4-dichlorotoluene with acetyl chloride or chloroacetyl chloride in the presence of a Friedel-Crafts catalyst and subsequently oxidizing the acetylated intermediate to give the carboxylic acid.
