52522-56-2Relevant academic research and scientific papers
Isolation, Synthesis And Structure Determination Of Cannabidiol Derivatives And Their Cytotoxic Activities
Nalli, Yedukondalu,Jan, Suraya,Lauro, Gianluigi,Ur Rasool, Javeed,Lone, Waseem I.,Sarkar, Aminur R.,Banday, Junaid,Bifulco, Giuseppe,Laatsch, Hartmut,Syed, Sajad H.,Ali, Asif
, p. 471 - 480 (2019/07/15)
In a continuing effort to explore the structural diversity and pharmacological activities of natural products based scaffolds, herein, we report the isolation, synthesis, and structure determination of cannabidiol and its derivatives along with their cytotoxic activities. Treatment of cannabidiol (1) with acid catalyst POCl3 afforded a new derivative 6 along with six known molecules 2 ? 5, 7 and, 8. The structure of 6 was elucidated by extensive spectroscopic analyses and DFT calculations of the NMR and ECD data. All the compounds (2–8) were evaluated for their cytotoxic potential against a panel of eight cancer cell lines. Compounds 4, 5, 7, and 8 showed pronounced in vitro cytotoxic activity with IC50 values ranging from 5.6 to 60 μM. Out of the active molecules, compounds 4, and 7 were found to be comparable to that of the parent molecule 1 on the inhibition of almost all the tested cancer cell lines.
Enantioselective total synthesis of (-)-Δ8-THC and (-)-Δ9-THC via catalytic asymmetric hydrogenation and S NAr cyclization
Cheng, Li-Jie,Xie, Jian-Hua,Chen, Yong,Wang, Li-Xin,Zhou, Qi-Lin
, p. 764 - 767 (2013/04/10)
The highly efficient asymmetric total syntheses of (-)-Δ8- tetrahydrocannabinol ((-)-Δ8-THC) (13 steps, 35%) and (-)-Δ9-tetrahydrocannabinol ((-)-Δ9-THC) (14 steps, 30%) have been developed by using ruthenium-ca
