52531-22-3

Usage

Uses

Used in Plant Growth Regulation:
4-Methylindole-3-acetic Acid is used as a plant growth regulator for its ability to modulate plant growth and development. It is particularly effective in promoting cell elongation, division, and differentiation, which can lead to increased crop yields and improved plant health.
Used in Agricultural Applications:
In the agricultural industry, 4-Methylindole-3-acetic Acid is used as a growth enhancer to improve the overall growth and productivity of crops. Its application can lead to better root development, stronger stems, and larger, more abundant fruits or seeds, ultimately contributing to higher agricultural outputs.
Used in Plant Tissue Culture:
4-Methylindole-3-acetic Acid is also utilized in plant tissue culture as a component of the growth medium. It aids in the successful growth and differentiation of plant cells, tissues, and organs in vitro, which is essential for plant propagation and genetic research.
Used in Pharmaceutical Research:
Due to its structural similarity to Indole-3-acetic acid, 4-Methylindole-3-acetic Acid may have potential applications in the pharmaceutical industry as a starting material for the synthesis of various bioactive compounds or as a tool in understanding the mechanisms of auxin action in plants and their potential therapeutic applications.

Upstream product

• 16096-32-5 4-methyl-1H-indole 
• 23084-32-4 4-methylindole-3-acetonitrile 

Relevant academic research and scientific papers

Asymmetric Dearomatizing Fluoroamidation of Indole Derivatives with Dianionic Phase-Transfer Catalyst

Asymmetric dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeds under mild reaction conditions to provide fluoropyrroloindoline derivatives in a highly enantioselective manner. Various substitution patterns on the indole ring are well tolerated. To facilitate the reaction and ensure reproducibility, the addition of water is essential, and its possible role is discussed.

A substituted indole -3 - acetic acid synthesis method (by machine translation)

The present invention provides a substituted indole - 3 - acetic acid synthesis method, comprises the following steps: (1) in order to replace the indole as the starting material, with the acylation reagent under the action of catalyst through the tutor - acylation to obtain the 1, 3 - diacetyl substituted indole; (2) intermediate 1, 3 - diacetyl substituted indole does not need refining, directly with the morpholine and sulfur by the Willgerodt - Kindler rearrangement reaction, the inorganic under the catalysis of alkali hydrolysis, acidified to obtain substituted indole - 3 - acetic acid. (by machine translation)

Synthesis and biological activities of 4-trifluoromethylindole-3-acetic acid: A new fluorinated indole auxin

In our studies on the development of new promoters for the root formation of tree cuttings, 4-trifluoromethylindole-3-acetic acid (4-CF3-IAA), a new fluorinated auxin, was synthesized via 4-trifluoromethylindole and 4-trifluoromethylindole-3-acetonitrile by using 2-methyl-3-nitrobenzotrifluoride as the starting material. As a control compound for comparing biological activities, 4-methylindole-3-acetic acid (4-CH3-IAA) was also synthesized by using 2,3-dimethylnitrobenzene as the starting material. The biological activities of these compounds were compared by three bioassays with those of indole-3-acetic acid and 4-chloroindole-3-acetic acid (4-Cl-IAA), which, like 4-CF3-IAA and 4-CH3-IAA, has a substituent at the 4-position of the indole nucleus. 4-CF3-IAA showed strong root formation-promoting activity with black gram cuttings which was 1.5 times higher than that of 4-(3-indole)butyric acid at 1 × 10-4 M. 4-CH 3-IAA, however, only weakly promoted root formation in spite of its strong inhibition of hypocotyl growth in Chinese cabbage and promotion of hypocotyl swelling and lateral root formation in black gram. On the other hand, 4-CF3-IAA demonstrated weaker activities than 4-CH3-IAA and 4-Cl-IAA in these two bioassays.

Compounds exhibiting thrombopoietin-like activities

The compounds of the invention are compounds represented by the following general formula (1): wherein E represents one selected from the group consisting of a methylidyne group and a nitrilo group, R1 represents one selected from the group consisting of optionally substituted aryl groups and optionally substituted heteroaryl groups, R2 represents one selected from the group consisting of a hydrogen atom and alkyl groups, W1 represents an amino acid residue, A represents one selected from the group consisting of a carbonyl group and a sulfonyl group, X1 represents one selected from the group consisting of optionally substituted alkylene groups and optionally substituted alkenylene groups, and p represents 0 or 1; and their pharmacologically acceptable salts, which exhibit thrombopoietin-like activity.