52533-64-9

Basic information

• Product Name: N-(-Bromovaleryl)methanesulfonamide
• Synonyms: 5-Bromo-N-(methylsulfonyl)pentanamide;N-(-Bromopentamoyl)methanesulfonamide;N-(-Bromovaleryl)methanesulfonamide
• CAS NO: 52533-64-9
• Molecular Formula: C6H12BrNO3S
• Molecular Weight: 258.13
• Mol File: 52533-64-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(-Bromovaleryl)methanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(-Bromovaleryl)methanesulfonamide(52533-64-9)
• EPA Substance Registry System: N-(-Bromovaleryl)methanesulfonamide(52533-64-9)

Safety Data

• Hazardous Substances Data: 52533-64-9(Hazardous Substances Data)

Upstream product

• 3144-09-0 methanesulfonamide 
• 4509-90-4 5-bromovaleroyl chloride 

Downstream Products

• 52533-65-0 [4-(methanesulfonylaminocarbonyl)-n-butyl]triphenylphosphonium bromide 

Relevant articles and documents

Synthesis and biological activity of carboxyl-terminus modified prostaglandin analogues

A series of PGE2, 16,16-dimethyl-PGE2, and PGF(2α), and PGF(2α) analogues modified at the carboxyl terminus with tetrazole, amide, acylurea, imide, and sulfonimide functionalities was evaluated for uterine stimulant, bronchodilator, hypotensive, gastric antisecretory, and diarrheal activity. These compounds were prepared by modification of the Corey prostaglandin synthesis utilizing as a key step condensation of known hemiacetals with the ylide derived from the requisite substituted phosphonium salts. Structure-activity relationships suggest that a proton at the C-1 position appears necessary for agonist activity and the acidity of this proton has a relatively greater influence on activity than pendant steric bulk. Noteworthy are the tissue-selective bronchodilator activity of N-acetyl-PGE2-carboxamide and the selectivity for uterine tissue of N-methanesulfonyl-PGE2-carboxamide, 2-decarboxy-2-(tetrazol-5-yl)-16,16-dimethyl-PGE2, N-acetyl-16,16-dimethyl-PGE2-carboxamide, and N-methanesulfony-PGE2-carboxamide, and N-methanesulfonyl-16,16-dimethyl-PGE2-carboxamide.

N-substituted prostaglandin carboxamides

The N-substituted prostaglandin carboxamides and various intermediates employed in their preparation. Such prostaglandin analogs exhibit the same activity profiles as the corresponding natural prostaglandin but with increased duration of action and increased selectivity of action.