52535-35-0Relevant academic research and scientific papers
A convenient synthesis of the key intermediate of selective COX-2 inhibitor Etoricoxib
Tartaggia, Stefano,Caporale, Andrea,Fontana, Francesco,Stabile, Paolo,Castellin, Andrea,De Lucchi, Ottorino
, p. 18544 - 18549 (2013/10/21)
An original strategy for the synthesis of ketone 1, the key intermediate for preparing Etoricoxib, an important nonsteroidal anti-inflammatory drug, has been developed. Inexpensive 5-hydroxy-2-methylpyridine was converted to the corresponding acetyl derivative in four practical synthetic steps. The following palladium-catalyzed α-arylation of acetylpicoline with 4-bromo- or 4-chlorophenyl methyl sulfone was efficiently optimized in order to afford ketone 1 in remarkable yield.
Folding of coordination polymers into double-stranded helical organization
Kim, Ho-Joong,Lee, Eunji,Kim, Min Gyu,Kim, Min-Cheol,Lee, Myongsoo,Sim, Eunji
supporting information; experimental part, p. 3883 - 3888 (2009/04/17)
Self-assembling coordination polymers based on PdII and Cu II metal ions were prepared from complexation of a bent-shaped bispyridine ligand and a corresponding transition metal. These coordination polymers were observed to self-assemble into supramolecular structures that differ significantly depending on the coordination geometry of the metal center. The polymer based on PdII self-assembles into a layer structure formed by bridging bispyri dine ligands connected in a trans-position of the square-planar coordination geometry of metal center. In contrast, the polymer based on CuII adopts a double-helical conformation with regular grooves, driven by interstranded, copper-chloride dimeric interaction. The double-stranded helical organization is further confirmed by structure optimization from density functional theory with aromatic framework, showing that the optimized double-helical structure is energetically favorable and consistent with the experimental results. These results demonstrate that weak metal-ligand bridging interactions can provide a useful strategy to construct stable double-stranded helical nanotubes.
