52537-88-9

Basic information

• Product Name: 2-[(4-METHOXY-PHENYLAMINO)-METHYL]-PHENOL
• Synonyms: ALPHA-(P-ANISIDINO)-ORTHO-CRESOL
• CAS NO: 52537-88-9
• Molecular Formula: C₁₄H₁₅NO₂
• Molecular Weight: 229.27
• Mol File: 52537-88-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 397.8°Cat760mmHg
• Flash Point: 194.4°C
• Appearance: /
• Density: 1.193g/cm³
• Vapor Pressure: 6.73E-07mmHg at 25°C
• Refractive Index: 1.636
• CAS DataBase Reference: 2-[(4-METHOXY-PHENYLAMINO)-METHYL]-PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-METHOXY-PHENYLAMINO)-METHYL]-PHENOL(52537-88-9)
• EPA Substance Registry System: 2-[(4-METHOXY-PHENYLAMINO)-METHYL]-PHENOL(52537-88-9)

Safety Data

• Hazardous Substances Data: 52537-88-9(Hazardous Substances Data)

Usage

General Description

2-[(4-Methoxy-phenylamino)-methyl]-phenol is a chemical compound with the molecular formula C14H15NO2. It is a phenol derivative that contains a methoxyphenylamino group and is often used in pharmaceutical research and drug development. This chemical compound has potential applications in the pharmaceutical industry due to its ability to interact with biological systems and its potential therapeutic properties. Its chemical structure and properties make it a promising candidate for the development of new drugs and medical treatments.

InChI:InChI=1/C14H15NO2/c1-17-13-8-6-12(7-9-13)15-10-11-4-2-3-5-14(11)16/h2-9,15-16H,10H2,1H3

Upstream product

• 90-02-8 salicylaldehyde 
• 104-94-9 4-methoxy-aniline 
• 116585-12-7 2-((tert-butyldimethylsilyl)oxy)benzaldehyde 
• 96013-79-5 {2-[(tert-butyldimethylsilyl)oxy]phenyl}methanol 
• 1354018-44-2 2-(tert-butyldimethylsilyloxy)benzyl nitrate 
• 889-08-7 (E)-2-(((4-methoxyphenyl)imino)methyl)phenol 
• 89-95-2 2-methyl-benzyl alcohol 
• 90-01-7 salicylic alcohol 
• 3155-16-6 diphenyl oxalate 
• 78666-54-3 N,N'-bis-(4-methoxy-phenyl)-methanediamine 
• 889-08-7 salicylidene-4-anisidine 
• 56-23-5 tetrachloromethane 
• 108-95-2 phenol 

Downstream Products

• 1207178-61-7 3-(4-methoxyphenyl)-2-(3-nitrophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine 
• 1207178-57-1 3-(4-methoxyphenyl)-2-(2-nitrophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine 
• 67-63-0 isopropyl alcohol 
• 1396314-95-6 2-(4-fluorophenyl)-3-(4-methoxyphenyl)-3,4-dihydro-2H-1,3-benzoxazine 
• 1207178-64-0 3-(4-methoxyphenyl)-2-(4-nitrophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine 
• 13411-91-1 1-(4-methoxyphenylazo)naphthalen-2-ol 
• 716317-00-9 2-benzyl-4-(4-methoxyphenyl)-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-3-one 
• 99779-30-3 2-chloro-N-(2-hydroxybenzyl)-N-(4-methoxyphenyl)acetamide 
• 716316-96-0 2-bromo-N-(2-hydroxybenzyl)-N-(4-methoxyphenyl)-3-phenylpropionamide 
• 622400-18-4 N-(2-hydroxybenzyl)-N-(4-methoxyphenyl)-3-phenylpropynamide 
• 104-94-9 4-methoxy-aniline 

Relevant articles and documents

Convenient Assembly of Privileged (Hetero)Arene-Fused Benzo[1.4]oxazepines by Two Tandem SNAr Events. Part 2 – The Use of o-[N-(Hetero)aryl]aminomethyl Phenols

As was anticipated based on mechanistic reasoning, bis-nucleophilic o-(arylamino)methyl phenols underwent a facile, base-promoted cyclocondensation with reactivity matched bis-electrophilic (hetero)aromatic substrates to give a rare type of substituted di

Improving C=N bond reductions with (Cyclopentadienone)iron complexes: Scope and limitations

Herein, we broaden the application scope of (cyclo-pentadienone)iron complexes 1 in C=N bond reduction. The catalytic scope of pre-catalyst 1b, which is more active than the “Kn?lker complex” (1a) and other members of its family, has been expanded to the catalytic transfer hydrogenation (CTH) of a wider range of aldimines and ketimines, either pre-isolated or generated in situ. The kinetics of 1b-promoted CTH of ketimine S1 were assessed, showing a pseudo-first order profile, with TOF = 6.07 h–1 at 50 % conversion. Moreover, the chiral complex 1c and its analog 1d were employed in the enantioselective reduction of ketimines and reductive amination of ketones, giving fair to good yields and moderate enantioselectivity.

Aminophenols as efficient ligand for copper-Catalyzed ullmann-Type synthesis of diaryl ethers

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