52548-84-2

Usage

Uses

Used in Organic Synthesis:
1-(2-Chloroethyl)-1,3-Dihydro-2H-Benzimidazol-2-One is used as a synthetic intermediate for the development of various chemical compounds. Its application in organic synthesis is due to its unique chemical structure, which allows for the creation of a wide range of products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-(2-Chloroethyl)-1,3-Dihydro-2H-Benzimidazol-2-One is used as a key component in the development of new drugs. Its chemical properties make it a valuable building block for the synthesis of various medicinal compounds, potentially leading to the discovery of novel therapeutic agents.
Used in Chemical Research:
1-(2-Chloroethyl)-1,3-Dihydro-2H-Benzimidazol-2-One is also utilized in chemical research to study the properties and reactions of benzimidazole derivatives. This helps researchers gain a deeper understanding of the structure-activity relationships and potential applications of these compounds in various fields.

InChI:InChI=1/C9H9ClN2O/c10-5-6-12-8-4-2-1-3-7(8)11-9(12)13/h1-4H,5-6H2,(H,11,13)

Upstream product

• 615-16-7 1,3-dihydro-2H-benzimidazol-2-one 
• 107-06-2 1,2-dichloro-ethane 
• 624-70-4 1-chloro-2-iodoethane 
• 615-16-7 1H-benzimidazol-2-ol 

Downstream Products

• 104087-50-5 1-(2-{4-[(1R,3S)-6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-piperazin-1-yl}-ethyl)-1,3-dihydro-benzoimidazol-2-one 

Relevant academic research and scientific papers

Benzimidazolidinone derivatives as muscarinic agents

Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.

N,N'-Linked 1,2-ethanediyl-poly(benzimidazolin-2-ones) and the X-ray crystal structure of a benzimidazolin-2-one trimer

A series of N,N'-linked 1,2-ethanediyl-poly(benzimidazolin-2-ones) that can be classified as podands, are described. Seven dimers (21-27), three trimers (28-30), a cyclic tetramer (31) and an open-chain benzimidazolin-2-one heptamer (32) have been prepared and characterized by 1H, 13C NMR and by MS. The crystal and molecular structure of the trimer, 1,3-bis-2-(2-oxobenzimidazol-1-yl)ethyl-2-oxobenzimidazole monohydrate (30) has been solved by X-Ray analysis. The benzi-midazolin-2-one fragments display a pattern of bond distances and angles similar to that of analogue derivatives retrieved form the CSD. The molecules are hydrogen bonded to four others in a continuous two-dimensional network by N-H···O=C and C-H···O=C interactions in which all N-H donors and O=C accepters are involved.