52549-19-6

Basic information

• Product Name: 2-(5-oxo-5H-chroMeno[2,3-b]pyridin-7-yl)propanoic acid
• Synonyms: 2-(5-oxo-5H-chroMeno[2,3-b]pyridin-7-yl)propanoic acid;α-Methyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic Acid
• CAS NO: 52549-19-6
• Molecular Formula: C15H11NO4
• Molecular Weight: 269.25214
• Mol File: 52549-19-6.mol

Chemical Properties

• Melting Point: 194-195 °C(Solv: 1,4-dioxane (123-91-1); water (7732-18-5))
• Boiling Point: 513.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.405±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• PKA: 4.17±0.10(Predicted)
• CAS DataBase Reference: 2-(5-oxo-5H-chroMeno[2,3-b]pyridin-7-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-oxo-5H-chroMeno[2,3-b]pyridin-7-yl)propanoic acid(52549-19-6)
• EPA Substance Registry System: 2-(5-oxo-5H-chroMeno[2,3-b]pyridin-7-yl)propanoic acid(52549-19-6)

Safety Data

• Hazardous Substances Data: 52549-19-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(5-oxo-5H-chroMeno[2,3-b]pyridin-7-yl)propanoic acid is used as a pharmaceutical compound for its potential anti-inflammatory properties. It is known to exhibit antihistaminic and anaphylactic activities, making it a promising candidate for the development of new drugs to treat inflammation-related conditions.
Used in Research and Development:
In the field of research and development, 2-(5-oxo-5H-chroMeno[2,3-b]pyridin-7-yl)propanoic acid serves as a valuable chemical entity for studying its structure-activity relationships and exploring its potential applications in drug discovery. Its unique molecular structure allows researchers to investigate its interactions with various biological targets and understand its mode of action.
Used in Chemical Synthesis:
2-(5-oxo-5H-chroMeno[2,3-b]pyridin-7-yl)propanoic acid can also be utilized as a synthetic intermediate or building block in the synthesis of more complex molecules with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science. Its versatile chemical structure enables the development of novel compounds with improved properties and functionalities.

Upstream product

• 52549-17-4 2-(5h-[1]benzopyrano[2,3-b]pyridin-7-yl)propionic acid 
• 52549-26-5 2-(p-α-carboxyethylphenoxy)nicotinic acid 

Downstream Products

• 52549-17-4 2-(5h-[1]benzopyrano[2,3-b]pyridin-7-yl)propionic acid 

Relevant articles and documents

Preparation method of pranoprofen impurity

The invention provides a preparation method of a pranoprofen impurity, which comprises the steps of A) heating a compound 1 and hydrogen peroxide in a solvent until reflux, and reacting to obtain a compound 2; b) mixing the compound 2, methanol and mixed acid, and carrying out esterification reaction to obtain a pranoprofen impurity crude product with a structure as shown in a formula I defined in the description; and C) recrystallizing the pranoprofen impurity crude product with the structure as shown in the formula I to obtain the pranoprofen impurity with the structure as shown in the formula I. According to the invention, (RS)-2-(10H-9-oxa-1-azaanthracene-6-yl) propionic acid (1) is taken as an initiator, two-step synthesis reaction is carried out to obtain a pranoprofen impurity crude product, recrystallization purification is carried out on the crude product to obtain a final product, namely, the pranoprofen impurity ((RS)-2-(9-oxa-10-ketone-1-azaanthracene-6-yl) methyl propionate), mass spectrum and nuclear magnetic detection are carried out on the product, the detection data result is consistent with the impurity structure information, and the purity and the yield are relatively high.

Substituted alkanoic acids and derivatives

Substituted alkanoic acids and derivatives thereof of the formula: SPC1 Wherein each of X1 and X2 is a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms; each of R1 and R2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; A is a carbonyl group, a methylene group or an alkylidene group having 2 to 4 carbon atoms; Y is --O--, --S-- or --N(R)-- [wherein R is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms]; Z is OH or Q--B--N(R3)(R4) [wherein Q is O (oxygen atom) or NH, B is an alkylene group having 1 to 4 carbon atoms and each of R3 and R4 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or R3 and R4 together with the adjacent nitrogen atom form a saturated heterocycle selected from the group consisting of pyrrolidine, piperidine, morpholine, piperazine and piperazine substituted by an alkyl group having 1 to 4 carbon atoms at the 4-position]; and ring P represents a pyridine or a pyridine N-oxide ring; and pharmaceutically acceptable salts thereof are useful as antirheumatics, analgesics, antipyretics and anti-inflammatory agents.