525565-93-9Relevant academic research and scientific papers
Acylhydrazide schiff bases: Synthesis and antiglycation activity
Khan, Khalid Mohammed,Taha, Muhammad,Rahim, Fazal,Fakhri, Muhammad Imran,Jamil, Waqas,Khan, Momin,Rasheed, Saima,Karim, Aneela,Perveen, Shahnaz,Choudhary, Mohammad Iqbal
, p. 929 - 937 (2013/07/26)
Acylhydrazide Schiff bases 1-27 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 16 (IC50 = 199.82 ± 10.6 μM), 27 (IC50 = 234.83 ± 10.28 μM), 2 (IC50 = 240.99 ± 4.2 μM), and 14 (IC50 = 276.2 ± 2.3 μM) showed antiglycation potential comparable to the standard rutin (IC50 = 294.50 ± 1.5 μM). From this study we identified a new series of potent antiglycating agents. A structure-activity relationship has been described, while all compounds were characterized by using different spectroscopic techniques.
Acylhydrazide Schiff bases: DPPH radical and superoxide anion scavengers
Khan, Khalid Mohammed,Taha, Muhammad,Naz, Farzana,Siddiqui, Salman,Ali, Sajjad,Rahim, Fazal,Perveen, Shahnaz,Choudhary, M. Iqbal
scheme or table, p. 705 - 710 (2012/09/08)
Acylhydrazide Schiff bases 1-27 were evaluated for their in vitro DPPH radical and superoxide anion scavenging activity. They showed a varying degree of DPPH radical scavenging activity with IC50 values between 31.25-473.59 μM. Compounds 8, 2, and 10 have IC50 values 31.25 ± 1.32, 34.40 ± 0.66, and 37.24 ± 0.4 μM, respectively. Standard npropylgallate showed an IC50 value 30.12 ± 0.27 μM. Acylhydrazides 1-27 exhibited in vitro superoxide anion scavenging activities with IC50 values in the range of 175.6-450.89 μM. Results demonstrated that acylhyrazides 8, 2, and 10 have DPPH scavenging activity, comparable to standard n-propyl gallate while acylhyrazides 1-27 were found to be less superoxide anion scavenging active than the standard n-propyl gallate (IC50 = 106.34 ± 1.6 μM).
