52558-39-1Relevant academic research and scientific papers
ORGANIC PHOSPHORUS COMPOUNDS 95. A SIMPLE METHOD FOR THE PREPARATION OF N-DIHYDROXYPHOSPHONYLMETHYL-GLYCINE (GLYPHOSATE)
Maier, Ludwig
, p. 65 - 67 (2007/10/02)
Interaction of N-benzylglycine, formaldehyde and phosphorous acid in 30percent HCl-solution produces N-benzyl-N-dihydroxyphosphonomethyl-glycine 1, in 90percent yield.Debenzylation of 1, dissolved in water with H2 in the presence of 5percent Pd/C as catalyst gives glyphosate 2 in quantitative yield.Key words: Mannich reaction; debenzylation; N-benzyl-N-dihydroxyphosphonylmethyl-glycine; N-dihydroxyphosphonylmethyl-glycine (glyphosate).
Process for the preparation of N-substituted aminomethylphosphonic acids
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, (2008/06/13)
A process for the preparation of an N-substituted aminomethylphosphonic acid comprising reacting a 2,5-diketopiperazine compound with phosphorous acid and formaldehyde in an acidic medium.
