52559-19-0

Usage

Type of Compound

Heterocyclic compound

Structure

Contains both an imidazole and pyridine ring

Pharmaceuticals

As a building block in the synthesis of biologically active compounds and as a starting material for the preparation of various pharmaceutical drugs.

Agrochemicals

May have pesticidal or herbicidal properties.

Further Research

Needed to explore its potential uses and applications in various fields.

Upstream product

• 2589-12-0 4,6-dichloro-3H-imidazo[4,5-c]pyridine 
• 100-51-6 benzyl alcohol 
• 2589-12-0 4,6-dichloro-1H-imidazo<4,5-c>pyridine 

Downstream Products

• 579486-54-7 2-(3-ethyl-4-methylanilino)-7-(4-methoxybutyl)-6-oxo-3-deazapurine 
• 1319731-90-2 2-(3-ethyl-4-methylanilino)-9-(4-methoxybutyl)-6-oxo-3-deazapurine 
• 579486-55-8 2-(3-ethyl-4-methylanilino)-7-(5-methoxypentyl)-6-oxo-3-deazapurine 
• 579486-56-9 2-(3-ethyl-4-methylanilino)-7-[4-(1-morpholinyl)butyl]-6-oxo-3-deazapurine 
• 1319731-91-3 2-(3-ethyl-4-methylanilino)-9-[4-(1-morpholinyl)butyl]-6-oxo-3-deazapurine 
• 579486-52-5 2-(3,4-dichlorobenzylamino)-7-(4-methoxybutyl)-6-oxo-3-deazapurine 
• 579486-53-6 2-(3,4-dichlorobenzylamino)-7-(5-methoxypentyl)-6-oxo-3-deazapurine 
• 579486-57-0 2-(3,4-dichlorobenzylamino)-7-[4-(1-morpholinyl)butyl]-6-oxo-3-deazapurine 
• 579486-58-1 2-(3,4-dichlorobenzylamino)-9-[4-(1-morpholinyl)butyl]-6-oxo-3-deazapurine 
• 579486-59-2 2-(3,4-dichlorobenzylamino)-7-[5-(1-morpholinyl)pentyl]-6-oxo-3-deazapurine 

Relevant academic research and scientific papers

SYK INHIBITORS

The present disclosure a Syk compound inhibitors, including state cancer and inflammation and various disease States thereof in the treatment of relates to the use of. In one aspect a particular embodiment, . given by formula I which is marked as a chemical structure of compound. In formula said, X 1, X 2, X 3, R 2, R 3, R 4, R 5, and Y has described herein is. The present disclosure of a formula I compounds or a pharmaceutically acceptable salt of pharmaceutical compositions including, mediated by Syk and to treat conditions a employing these compounds and compositions further provides a method. (by machine translation)

7-Alkyl-N2-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity

Several 2-anilino- and 2-benzylamino-3-deaza-6-oxopurines [3-deazaguanines] and selected 8-methyl and 8-aza analogs have been synthesized. 7-Substituted N2-(3-ethyl-4-methylphenyl)-3-deazaguanines were potent and selective inhibitors of Gram+ bacterial DNA polymerase (pol) IIIC, and 7-substituted N2-(3,4-dichlorobenzyl)-3-deazaguanines were potent inhibitors of both pol IIIC and pol IIIE from Gram+ bacteria, but weakly inhibited pol IIIE from Gram- bacteria. Potent enzyme inhibitors in both classes inhibited the growth of Gram+ bacteria (MICs 2.5-10 μg/ml), and were inactive against the Gram- organism Escherichia coli. Several derivatives had moderate protective activity in Staphylococcus aureus-infected mice.

Purine and isosteric antibacterial compounds

The invention features 2,7-disubstituted purines and their isosteres such as the corresponding 3-deazapurines and 3-deaza-8-azapurines. The compounds disclosed herein have potent anti-microbial, e.g., anti-bacterial and anti-mycoplasmal properties. The compounds described herein inhibit DNA polymerase IIIC and DNA polymerase IIIE species; the compounds thus inhibit the growth of bacteria and mycoplasmata. The compounds can be administered to prevent or to treat Gram-positive or Gram-negative bacterial or mycoplasmal infections, e.g., in eukaryotic cell cultures, animals, or humans.