525599-49-9Relevant academic research and scientific papers
SUBSTITUTED-PYRIDINYL COMPOUNDS AND USES THEREOF
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Page/Page column 45-46; 54-55, (2020/01/10)
The present application relates generally to compounds useful for the treatment and/or enhancement of cognitive dysfunction and negative symptoms associated with CNS disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.
CYCLOBUTANE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED POTASSIUM CHANNELS
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Page/Page column 113-114, (2018/02/28)
The present invention provides compounds of the formula (I) and their use as Kv3 modulators.
Highly diastereoselective synthesis of 2-monosubstituted 1R,5S(1S,5R)-glycoluriles on the basis of S- and R-N-carbamoyl-α-amino acids
Kravchenko, Angelina N.,Chegaev, Konstantin Yu.,Chikunov, Il'ya E.,Belyakov, Pavel A.,Maksareva, Elena Yu.,Lyssenko, Konstantin A.,Lebedev, Oleg V.,Makhova, Nina N.
, p. 269 - 271 (2007/10/03)
The reactions of 4,5-dihydroxyimidazolidin-2-one with chiral S- and R-N-carbamoyl-α-amino acids occur diastereoselectively with the formation of corresponding 1R,5S(1S,5R)-glycoluriles as predominant diastereomers; the absolute configuration is determined
